PhD theses

S. van Rootselaar, Synthesis of piperidine and furopyrrolidine alkaloids, supervisor F. P. J. T. Rutjes, co-supervisor D. Blanco Ania, August 28, 2023.
https://repository.ubn.ru.nl/handle/2066/294806
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J. Merx, Epigenetics & Biomarkers. Exploring Modifications of Histone Tail Peptides & Novel Biomarker Discovery with Infrared Ion Spectroscopy, supervisor F. P. J. T. Rutjes, co-supervisors T. J. Boltje, J. Mecinovic, December 16, 2022.
https://repository.ubn.ru.nl/handle/2066/285383
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S.J. Moons, Altering the Glycome Using Sialomimetics, supervisor F. P. J. T. Rutjes, co-supervisor T. J. Boltje, November 10, 2022.
https://repository.ubn.ru.nl/handle/2066/283339
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J. Pijnenborg, Development of substrate based inhibitors targeting human glycosylation, supervisor F. P. J. T. Rutjes, co-supervisor T. J. Boltje, September 23, 2022.
https://repository.ubn.ru.nl/handle/2066/252747
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G. Belletti, Solid state deracemization. Viedma ripening versus temperature cycling, supervisors E. Vlieg, F.P.J.T. Rutjes, co-supervisor: H.L.M. Meekes, October 27, 2021
https://repository.ubn.ru.nl/handle/2066/236273
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H. Elferink, Exploring Glycosyl Cations, supervisor F.P.J.T. Rutjes, co-supervisor T.J. Boltje, May 20, 2021.
https://repository.ubn.ru.nl/handle/2066/233139
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V.R.L.J. Bloemendal, One-Flow Synthesis of Cannabinoids and Neuraminic Acids, supervisors F.P.J.T. Rutjes, J.C.M. van Hest, March 26, 20
https://pure.tue.nl/ws/portalfiles/portal/169602772/20210326_Bloemendal.pdf
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A.H.K. Al Temimi, Investigation of Methylation Catalysis of Unnatural Histone Peptides by Histone Lysine Methyltransferases, supervisor F.P.J.T. Rutjes, co-supervisor J. Mecinovic, June 19, 2020
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https://repository.ubn.ru.nl/handle/2066/219231
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D.C. Lenstra, Design, Synthesis and Evaluation of Histone Lysine Methyltransferase Inhibitors, supervisor F.P.J.T. Rutjes, co-supervisor J. Mecinovic, February 28, 2020.
https://repository.ubn.ru.nl/handle/2066/215062
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L. P. W. M. Lelieveldt, Chemical Strategies for Antigen-Selective Targeting of Autoreactive B Cells, supervisors G.J.M. Pruijn, F.P.J.T. Rutjes, co-supervisor: K.M. Bonger, May 8, 2019.
https://repository.ubn.ru.nl/handle/2066/202990

A. H. J. Engwerda, Deracemization on the Edge of Stability, supervisors E. Vlieg, F.P.J.T. Rutjes, co-supervisor: H. Meekes, February 14, 2019.
https://repository.ubn.ru.nl/handle/2066/201540

I. Bernar, Palladium-Catalyzed Synthesis of N-Heterocycles From Alkoxyallenes and Sulfonyl Ynamines, supervisor F.P.J.T. Rutjes, co-supervisor D. Blanco-Ania, November 29, 2018.
https://repository.ubn.ru.nl/handle/2066/199718

S. Eising, Coordination-Mediated Bioconjugation: Vinylboronic Acids as Bioorthogonal Reactants in the Tetrazine Ligation, supervisor F.P.J.T. Rutjes, co-supervisor: K.M. Bonger, November 20, 2018.
https://repository.ubn.ru.nl/handle/2066/197532

T. Heise, Chemical Glycobiology of Sialic Acid Derivatives for Glycocalyx Engineering, supervisor F.P.J.T. Rutjes, co-supervisor T.J. Boltje, August 21, 2018.
https://repository.ubn.ru.nl/handle/2066/192438

A. Riesco Dominguez, Synthesis of Fluorine-Containing Nitrogen-Based Heterocycles, supervisor F.P.J.T. Rutjes, co-supervisor: D. Blanco-Ania, September 10, 2018.
https://repository.ubn.ru.nl/handle/2066/194844

R.A. Mensink, Selective 1,2-cis Glycosylations Employing Stereodirecting Groups, supervisor F.P.J.T. Rutjes, co-supervisor: T.J. Boltje, February 22, 2018.
https://repository.ubn.ru.nl/handle/2066/183219

B.J.A. van Weerdenburg, Catalytic systems for (non)-hydrogenative para-hydrogen induced polarization, supervisor F.P.J.T. Rutjes, co-supervisors M.C. Feiters, M. Tessari October 6, 2016.
http://repository.ubn.ru.nl/handle/2066/159758


R.E. Steendam, A Solid Approach to Asymmetric Synthesis, supervisors E. Vlieg, F.P.J.T. Rutjes, co-supervisors H. Meekes, W. van Enckevort, October 6, 2015.
http://repository.ubn.ru.nl/handle/2066/143231


M.C.M. van Oers, Asymmetric catalysis in polymersome nanoreactors, supervisors F.P.J.T. Rutjes, J.C.M. van Hest, June 12, 2015.
http://repository.ubn.ru.nl/handle/2066/140662


F. van der Pijl, An aza-Achmatowicz approach to functionalized piperidines, supervisor F.P.J.T. Rutjes, co-supervisor F.L. van Delft, April 16, 2015.
http://repository.ubn.ru.nl/handle/2066/140068


K. Koch, Chemoenzymatic reactions in continuous flow microreactors, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, October 3, 2014.
http://repository.ubn.ru.nl/handle/2066/135194


R. P. Temming, Strain-promoted cycloadditions for (glyco)protein research, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, March 17, 2014.
http://repository.ubn.ru.nl/handle/2066/124284


S. A. M. W. van den Broek, Highly functionalized piperidines via ring-closing metathesis of dehydroamino acids, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, January 31, 2014.
http://repository.ubn.ru.nl/handle/2066/126486


A. E. M. Wammes, Design, synthesis and orthogonal immobilization of peptide and protein ligands, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, co-supervisor F. L. van Delft, January 21, 2014.
http://repository.ubn.ru.nl/handle/2066/120767


M. M. E. Delville, Organic synthesis in continuous flow: Towards integrated multiple processes, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, January 9, 2014.
http://repository.ubn.ru.nl/handle/2066/121820


J. S. Willemsen, Compartmentalized catalysis, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, January 8, 2014.
http://repository.ubn.ru.nl/handle/2066/122867


J. M. M. Verkade, Applications and industrial viability of organocatalysed Mannich reactions, supervisor F. P. J. T. Rutjes, co-supervisors F. L. van Delft, P. J. L. M. Quaedflieg, October 25, 2013.
http://repository.ubn.ru.nl/handle/2066/115712


M. F. Debets, Dibenzoazacyclooctynes: Synthesis and bioconjugation, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, co-supervisor F. L. van Delft, June 24, 2013.
http://repository.ubn.ru.nl/handle/2066/107700


H. A. van Kalkeren, An in situ reduction approach to organophosphorus catalysis, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, June 19, 2013.
http://repository.ubn.ru.nl/handle/2066/107694


R. P. Brinkhuis, Polymeric vesicles for drug delivery over the blood-brain barrier and in vivo Imaging, supervisors J. C. M. van Hest, F. P. J. T. Rutjes, December 9, 2012.
http://repository.ubn.ru.nl/handle/2066/100612


L. J. C. van Hemert, Chemoenzymatic aldol reactions: Applications of a four-enzyme catalytic cascade reaction, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, November 1, 2012.
http://repository.ubn.ru.nl/handle/2066/100599


P. J. Nieuwland, Organic synthesis in microreactors: development of continuous flow optimization and scale-up strategies, supervisors F. P. J. T. Rutjes, J. C. M. van Hest, October 3, 2012.
http://repository.ubn.ru.nl/handle/2066/100595


R. J. A. M. de Beer, Chemoenzymatic peptide synthesis through enzyme-specific activation, supervisor F. P. J. T. Rutjes, co-supervisors F. L. van Delft, S. Nabuurs, September 5, 2012.
http://repository.ubn.ru.nl/handle/2066/94178


C. Soares de Melo, Synthesis and biological evaluation of febrifugine and derivatives as potential antimalarial agents, supervisors F. P. J. T. Rutjes, K. Chibale (University of Cape Town, South-Africa), December 5, 2011.
http://repository.ubn.ru.nl/handle/2066/92393


B. Ritzen, Chemoenzymatic formation of biologically relevant nitrogen heterocycles, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, November 10, 2011.
http://repository.ubn.ru.nl/handle/2066/91276


D. C. J. Waalboer, Synthetic studies on terpene natural products.Total synthesis of (-) Platencin (-)-Dehydrohoplatencin and (+) Integroc Acid, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, February 21, 2011.
http://repository.ubn.ru.nl/handle/2066/92397


J. Kaiser, Cyclic enediyne-containing amino acids, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, February 4, 2011.
http://repository.ubn.ru.nl/handle/2066/83181


J. G. O. Cremers, Fluorous chemistry applications in synthesis and catalysis, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, September 13, 2010.
http://repository.ubn.ru.nl/handle/2066/83518


W. M. Aslam, Tuning of aminoglycoside properties by synthetic diversification: , supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, April 12, 2010.
http://repository.ubn.ru.nl/handle/2066/76557


M. A. Wijdeven, Chemoenzymatic formation of hydroxypiperidines: Total synthesis of (+)-epiquinamide and (+)-febrifugine, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, January 21, 2010.
http://repository.ubn.ru.nl/handle/2066/74882


M. Huibers, Sulfation via sulfite and sulfate diesters and synthesis of biologically relevant organosulfates, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, October 9, 2009.
http://repository.ubn.ru.nl/handle/2066/75818


D. Blanco Ania, Parallel synthesis of potential drugs based on the 2-arylethyl amine moiety, supervisor F. P. J. T. Rutjes, co-supervisor H. W. Scheeren, October 9, 2009.
http://repository.ubn.ru.nl/handle/2066/75765


D. Girones Delgado-Urena, Exploration of synthetic methodologies in the preparation of neamine-type RNA ligands, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, February 26, 2009.
http://repository.ubn.ru.nl/handle/2066/65659


S. Groothuys, Glycoacetylenes in the synthesis and application of stable glycoamino acids and peptides, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, December 1, 2008.
http://repository.ubn.ru.nl/handle/2066/72376


S. S. van Berkel, Thrombin generation: Molecules and tools, supervisors F. P. J. T. Rutjes, H. C. Hemker (UM), co-supervisor F. L. van Delft, November 3, 2008.
http://repository.ubn.ru.nl/handle/2066/72445


B. H. M. Kuijpers, Triazole-linked glycosylamino acids and peptides: synthesis, scope and applications, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, October 23, 2008.
http://repository.ubn.ru.nl/handle/2066/65595


V. De Matteis, Synthesis of fluoride- and trifluoromethyl-substituted heterocycles via ring-closing metathesis, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, March 19, 2008.
http://repository.ubn.ru.nl/handle/2066/72549


K. F. W. Hekking, Ring-closing metathesis of functionalized olefins: key to heterocyclic building blocks and natural products, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, September 25, 2007.
http://repository.ubn.ru.nl/handle/2066/30187


B. W. T. Gruijters, Affinity separation based on hydrogen bonding: scope and limitations in synthetic applications, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, June 14, 2007.
http://repository.ubn.ru.nl/handle/2066/30015


M. IJsselstijn, Synthesis of conformationally restricted beta-turn mimics, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, October 30, 2006.
http://repository.ubn.ru.nl/handle/2066/29815


G. F. Busscher, Asymmetric synthesis of 2-deoxystreptamine analogues as potential RNA ligands, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, June 13, 2006.
http://repository.ubn.ru.nl/handle/2066/27450


T. M. Kooistra, Olefin polymerization with late transition metals and nitrogen donor ligands, supervisor F. P. J. T. Rutjes, co-supervisor P. H. M. Budzelaar, March 2, 2005.
http://repository.ubn.ru.nl/handle/2066/19603


H. L. van Lingen, New oxazoline-based ligands for application in asymmetric synthesis, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, February 2, 2005.
http://repository.ubn.ru.nl/handle/2066/32780


B. C. J. van Esseveldt, Synthesis of multi-functional building blocks from acetylene-containing α-amino acids, supervisor F. P. J. T. Rutjes, co-supervisor F. L. van Delft, October 14, 2004.
http://repository.ubn.ru.nl/handle/2066/19510


S. S. Kinderman, Transition metal catalyzed formation and transformations of allylic N,O-acetals, supervisors F. P. J. T. Rutjes, H. Hiemstra, December 16, 2003. 1.
http://hdl.handle.net/11245/1.215257


S. T. H. Willems, Rhodium olefin complexes of diiminate type ligands, supervisors A. W. Gal, F. P. J. T. Rutjes, co-supervisor P. H. M. Budzelaar, December 12, 2003.
http://repository.ubn.ru.nl/handle/2066/19374


M. K. S. Vink, From nitriles to nitrogen heterocycles: chemoenzymatoc approaches toward diversely substituted enantiopure building blocks, supervisors F. P. J. T. Rutjes, H. E. Schoemaker, October 31, 2003.
http://hdl.handle.net/11245/1.212580


R. Doodeman, Synthesis of oxygen and nitrogen heterocycles via stabilized carbocations and ring-closing metathesis, supervisors H. Hiemstra, F. P. J. T. Rutjes, co-supervisor J. H. van Maarseveen, October 28, 2002.
http://hdl.handle.net/11245/1.200486


W. J. N. Meester, Combinatorial applications of N-acylimnium ion intermediates in the synthesis of homoallylic amines, supervisors F. P. J. T. Rutjes, H. Hiemstra, co-supervisor J. H. van Maarseveen, September 17, 2002.
http://hdl.handle.net/11245/1.200487


J. J. N. Veerman, Novel parallel synthesis routes to nitrogen heterocycles via N-acyliminium ions, supervisors F. P. J. T. Rutjes, H. Hiemstra, co-supervisor J. H. van Maarseveen, May 28, 2002.
http://hdl.handle.net/11245/1.200488


J. C. J. Benningshof, Studies towards the total synthesis of solanoeclepin A: synthesis of analogues containing the tetracyclic left-hand substructureal, supervisors H. Hiemstra, F. P. J. T. Rutjes, September 14, 2001.
http://hdl.handle.net/11245/1.184604


R. H. Blaauw, Intramolecular [2+2]photocycloadditions as an approach towards the right-hand side of solanoeclepin A, supervisors H. Hiemstra, F. P. J. T. Rutjes, June 29, 2001.
http://hdl.handle.net/11245/1.184605


L. B. Wolf, Synthesis and applications of unsaturated non-proteinogenic α-H-α-amino acids, supervisors F. P. J. T. Rutjes, H. E. Schoemaker, May 31, 2001.
http://hdl.handle.net/11245/1.184658


W. F. J. Karstens, Palladium-catalyzed cyclization reactions of allene- and acetylene-substituted lactams, supervisors H. Hiemstra, F. P. J. T. Rutjes, June 7, 2000.
http://hdl.handle.net/11245/1.178592