Faculty of Science

Delen

Publications


  • Biomimetic stress sensitive hydrogel controlled by DNA nanoswitches 
    S.R. Deshpande, R. Hammink, F.T.H. Nelissen, A.E. Rowan, and H.A. Heus
    Biomacromolecules (2017), 18, 3310-17. DOI: 10.1021/acs.biomac.7b00964
  • A membrane-anchored aptamer sensor for probing of IFNγ secretion by single cells
    L. Qiu, F.Wimmers, J. Weijden, H.A. Heus, J. Tel, and C.G. Figdor
    Chem. Comm. (2017), 53, 8066 - 69. DOI: 10.1039/c7cc03576d
  • DNA-responsive polyisocyanopeptide hydrogels with stress-stiffening capacity
    S.R. Deshpande, R. Hammink, R.K. Das,  F. H. T. Nelissen , K.G. Blank, A.E. Rowan, and H.A. Heus
    Adv Funct Mat (2016), 26, 9075-82. DOI: 10.1002/adfm.201602461
  • Protein Synthesis in Coupled and Uncoupled Cell-Free Prokaryotic Gene Expression Systems
    M.M. Hansen, M. Ventosa Rosquelles, M.Yelleswarapu, R.J. Maas, A.J. van Vugt-Jonker, H.A.Heus , and W.T.S. Huck 
    ACS Synth Biol  (2016) 5, 1433-1440. DOI: 10.1021/acssynbio.6b00010
  • Cell-Like Nanostructured Environments Alter Diffusion and Reaction Kinetics in Cell-Free Gene Expression.
    M.M. Hansen, S. Paffenholz, D. Foschepoth, H.A. Heus , J. Thiele, and W.T. S. Huck 
    Chembiochem (2016), 17, 228-32. DOI: 10.1002/cbic.201500560
  • Macromolecular crowding creates heterogeneous environments of gene expression in picolitre droplets.
    M. M. Hansen, L. H. Meijer, E. Spruijt, R. J. Maas, M. V. Rosquelles, J. Groen, H. A. Heus, and W. T. S. Huck  
    Nature nanotechnology (2016), 11, 191-7. DOI: 10.1038/NNANO.2015.243
  • Stable isotope labeling methods for DNA 
    F.H.T. Nelissen, M. Tessari, S.S. Wijmenga, and H.A. Heus.
    Prog Nucl Magn Reson Spectrosc (2016), 96, 89-108. DOI: 10.1016/j.pnmrs.2016.06.001
  • Associative interactions in crowded solutions of biopolymers counteract depletion effects
    J. Groen, D. Foschepot, E. te Brinke, A.J. Boersma, H. Imamura, G. Rivas, H.A. Heus, and W. T. S. Huck  
    J Am Chem Soc (2015), 137, 13041-48. DOI: 10.1021/jacs.5b07898
  • Production of homogeneous recombinant RNA using a tRNA scaffold and hammerhead ribozymes
    F.H.T. Nelissen, H.A Heus, and S.S. Wijmenga  
    Methods Mol Biol. (2015), 1316, 33-44. DOI: 10.1007/978-1-4939-2730-2_4
  • Enzymatic preparation of multimilligram amounts of pure single-stranded DNA samples for material and analytical sciences
    F.H.T. Nelissen, E.P.M. Goossens, M. Tessari, and H.A. Heus   
    Anal Biochem (2015), 475, 68-73. DOI: 10.1016/j.ab.2015.01.014
  • DNA-functionalized hydrogels for confined membrane-free in vitrotranscription/translation.
    J. Thiele, Y. Ma, D. Foschepoth, M.M. Hansen, C. Steffen, H.A. Heus, and W.T.H. Huck 
    Lab  Chip (2014), 14, 2651-56. DOI: 10.1039/c3lc51427g
  • Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate
    Sokolova, E., Spruijt, E., Hansen, M.M.K., Dubuc, E., Groen, J., Chokkalingam, V., Piruska, A., Heus, H.A., and Huck, W.T.S. 
    Proc Natl Acad Sci U S A (2013), 110, 11692-11697. DOI: 10.1073/pnas.1222321110
  • Structural and thermodynamic signatures that define pseudotriloop RNA hairpins
    van der Werf R., Wijmenga S.S., Heus H.A., and Olsthoorn R.C. 
    RNA (2013), 19 , 1833-9. DOI: 10.1261/rna.039636.113
  • Fast production of homogeneous recombinant RNA - towards large-scale production of RNA
    F.H. Nelissen, E.H. Leunissen, L. van de Laar, M. Tessari, H.A. Heus, and S.S. Wijmenga
    Nucleic Acids Research (2012) 40, e102
  • Force spectroscopy of Rev-peptide-RRE interaction from HIV-1
    J. Zivkovic, L. Janssen, F. Alvarado, S. Speller, and H.A. Heus
    Soft Matter (2012) 8, 2103-2109

  • Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV
    J. Zoll, M. M. Hahn, P. Gielen, H. A. Heus, W. J. Melchers, and F. J. van Kuppeveld
    PLoS One (2011) 6, e24818

  • Isotape labeling of larger DNA for NMR structural studies
    S.S. Wijmenga, F. Nelissen, H.A. Heus and M. Tessari 
    In: Advances in biomedical spectroscopy, advances in bioNMR spectroscopy, (2011) Eds.: S. Pascal & A. Dingley

  • Atomic force microscope-based single-molecule force spectroscopy of RNA unfolding
    H. A. Heus, E. M. Puchner, A. J. van Vugt-Jonker, J. L. Zimmermann and H. E. Gaub
    Anal Biochem (2011) 414, 1-6

  • Isotope labeling of larger DNAs for NMR structural studies
    S.S. Wijmenga, F.T.H. Nelissen, H.A. Heus, and M. Tessari
    In advances in biomedical spectroscopy, Volume 3, Biomolecular NMR spectroscopy, eds. A.J. Dingley and S.M. Pascal, IOS press (2011)

  • Enzymatic stereospecific preparation of fluorescent S-adenosyl-L-methionine analogs
    O. M. Ottink, F. H. T. Nelissen, Y. Derks, S. S. Wijmenga and H. A. Heus
    Anal Biochem (2010) 396, 280-283

  • (1)H and (13)C resonance assignments of a guanine sensing riboswitch's terminator hairpin
    O. M. Ottink, I. M. Westerweele, M. Tesssari, F. H. Nelissen, H. A. Heus and S. S. Wijmenga
    Biomol NMR Assign. (2010) 4, 89-91

  • Network theory approach for data evaluation in the dynamic force spectroscopy of biomolecular interactions
    J. Zivkovic, M. Mitrovic, L. Janssen, H. A. Heus, B. Tadic and S. Speller 
    Epl (2010) 89, 68004
  • Functional analysis of the SRV-1 RNA frameshifting pseudoknot
    R. C. L. Olsthoorn, R. Reumerman, C. W. Hilbers, C. W. A. Pleij and H. A. Heus
    Nucleic Acids Res (2010) 38, 7665-7672
  • The structure-function relationship of the enterovirus 3'-UTR
    J. Zoll, H. A. Heus, F. J. van Kuppeveld and W. J. Melchers
    Virus Res (2009) 139, 209-16
  • Preparation of selective and segmentally labeled single-stranded DNA for NMR by self-primed PCR and asymmetrical endonuclease double digestion
    F. H. Nelissen, F. C. Girard, M. Tessari, H. A. Heus and S. S. Wijmenga
    Nucleic Acids Res (2009) 37, e114
  • Cartilage-hair hypoplasia-associated mutations in the RNase MRP P3 domain affect RNA folding and ribonucleoprotein assembly
    T. J. Welting, S. Mattijssen, F. M. Peters, N. L. van Doorn, L. Dekkers, W. J. van Venrooij, H. A. Heus, L. Bonafe and G. J. Pruijn
    Biochim Biophys Acta (2008) 1783, 455-66`
  • Multiple segmental and selective isotope labeling of large RNA for NMR structural studies
    F. H. Nelissen, A. J. van Gammeren, M. Tessari, F. C. Girard, H. A. Heus and S. S. Wijmenga
    Nucleic Acids Res 36 (2008) e89
  • Ligand-induced folding of the guanine-sensing riboswitch is controlled by a combined predetermined induced fit mechanism
    O. M. Ottink, S. M. Rampersad, M. Tessari, G. J. Zaman, H. A. Heus and S. S. Wijmenga
    RNA (2007) 13, 2202-12
  • Transcription and translation regulation riboswitches. Structure of the guanine sensing riboswitch in its guanine-free and -bound forms and comparison with the SAM riboswitch type II
    O. Ottink, S. Rampersad, M. Tessari, F. Nelissen, H. A. Heus and S. Wijmenga
    J Biomol Struct Dyn (2007) 24, 697
  • DNA and RNA branching: NMR structural studies
    S. Wijmenga, O. Ottink, S. Rampersad, M. Tessari, F. Nelissen, H.A. Heus, F. Girard, B. Wu, C.E. Pearson, R. van der Werf
    J Biomol Struct Dyn (2007) 24, 669
  • Nonspecific protein adsorption at the single molecule level studied by atomic force microscopy
    P. Schon, M. Gorlich, M.J. Coenen, H.A. Heus and S. Speller
    Langmuir (2007) 23, 9921-3
  • Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs
    J. Zoll, M. Tessari, F.J. Van Kuppeveld, W.J. Melchers and H.A. Heus
    RNA (2007) 13, 781-92
  • An RNA conformational shift in recent H5N1 influenza A viruses
    A.P. Gultyaev, H.A. Heus and R.C. Olsthoorn
    Bioinformatics (2007) 23, 272-6
  • Macroscopic hierarchical surface patterning of porphyrin trimers via self-assembly and dewetting
    R. van Hameren, P. Schon, A.M. van Buul, J. Hoogboom, S.V. Lazarenko, J.W. Gerritsen, H. Engelkamp, P. C. Christianen, H.A. Heus, J.C. Maan, T. Rasing, S. Speller, A.E. Rowan, J.A. Elemans and R.J. Nolte
    Science (2006) 314, 1433-6
  • AFM Studies on beta-Sheet Block Copolymers at Solid Surfaces: High-Resolution Structures and Aggregation Dynamics
    P. Schön, J.M. Smeenk, S. Speller, H.A. Heus, and J.C.M. van Hest
    Australian J. of Chem. (2006), 59, 560 – 563.
  • Structural and functional integrity of the coxsackievirus ori/R: the spacing in-between coaxial RNA helices
    M.J.M. van Ooij, D.H.R.F. Glaudemans, H.A. Heus, F.J.M. van Kuppeveld, and W.J.G. Melchers 
    J. Gen. Virol. (2006), 87, 689-895.

  • Chemical synthesis of picornaviral protein primers of RNA replication
    N.M. Kriek, N.J. Meeuwenoord, H. van den Elst, H.A. Heus, G.A. van der Marel and D.V. Filippov
    Org Biomol Chem (2006) 4, 3576-86
  • A GCUA tetranucleotide loop found in the poliovirus oriL by in vivo SELEX (un)expectedly forms a YNMG-like structure: Extending the YNMG family with GYYA
    W.J. Melchers, J. Zoll, M. Tessari, D.V. Bakhmutov, A.P. Gmyl, V.I. Agol and H.A. Heus
    RNA (2006) 12, 1671-82
  • Novel application of sRNA: Stimulation of ribosomal frameshifting
    R.C.L. Olsthoorn, M. Laurs, F. Sohet, C.W. Hilbers, H.A. Heus and C.W.A. Pleij
    RNA 10 (2004) 1702-1703
  • Structures of non-canonical tandem base pairs in RNA helices: Review
    H.A. Heus and C.W. Hilbers
    Nucleosides Nucleotides & Nucleic Acids 22 (2003) 559-571
  • Structure of the pyrimidine-rich internal loop in the poliovirus 3 '-UTR: The importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs
    E.M.H.P. Lescrinier, M. Tessari, F.J.M. van Kuppeveld, W.J G. Melchers, C.W. Hilbers and H.A. Heus
    Journal Of Molecular Biology 331 (2003) 759-769
  • Solution structure of the pseudoknot of SRV-1 RNA, involved in ribosomal frameshifting
    P.J.A. Michiels, A.A M. Versleijen, P.W. Verlaan, C.W.A. Pleij, C.W. Hilbers and H.A. Heus
    Journal Of Molecular Biology 310 (2001) 1109-1123
  • Classic folds in RNA molecules
    C.W. Hilbers, P.J.A. Michiels and H.A. Heus
    in Dynamics, structure and function of biological macromolecules. O. Jardetzky and M.D. Finucane Eds., NATO Science Series 315, 164-175 (2001)
  • Structure of the ribozyme substrate hairpin of Neurospora VS RNA: A close look at the cleavage site
    P.J.A. Michiels, C.H.J. Schouten, C.W. Hilbers and H.A. Heus
    RNA 6 (2000) 1821-1832
  • Solution structure of a HNA-RNA hybrid
    E.M.H.P. Lescrinier, R. Esnouf, J. Schraml, R. Busson, H.A. Heus, C.W. Hilbers and P. Herdewijn
    Chemistry & Biology 7 (2000) 719-731
  • Solution structure of a RNA decamer duplex, containing 9-[2-O-(beta-D-ribofuranosyl)-beta-D-ribofuranosyl]adenine, a special residue in lower eukaryotic initiator tRNAs
    I. Luyten, R.M. Esnouf, S.N. Mikhailov, E.V. Efimtseva, P.J.A. Michiels, H.A. Heus, C.W. Hilbers and P. Herdewijn
    Helvetica Chimica Acta 83 (2000) 1278-1289
  • Structure of the 3 '-hairpin of the TYMV pseudoknot: preformation in RNA folding
    M.H. Kolk, M. van der Graaf, C.T.M. Fransen, S.S. Wijmenga, C.W.A. Pleij, H.A. Heus and C.W. Hilbers
    EMBO Journal 17 (1998) 7498-7504
  • On the NMR structure determination of a 44n RNA pseudoknot: Assignment strategies and derivation of torsion angle restraints
    M.H. Kolk, S.S. Wijmenga, H.A. Heus and C.W. Hilbers
    Journal Of Biomolecular NMR 12 (1998) 423-433
  • NMR structure of a classical pseudoknot: Interplay of single- and double-stranded RNA
    M.H. Kolk, M. van der Graaf, S.S. Wijmenga, C.W.A. Pleij, H.A. Heus and C.W. Hilbers
    Science 280 (1998) 434-438
  • The detailed structure of tandem G-A mismatched base-pair motifs in RNA duplexes is context dependent
    H. A. Heus, S. S. Wijmenga, H. Hoppe and C. W. Hilbers
    Journal Of Molecular Biology 271 (1997) 147-158
  • The structure of the isolated, central hairpin of the HDV antigenomic ribozyme: Novel structural features and similarity of the loop in the ribozyme and free in solution
    M. H. Kolk, H. A. Heus and C. W. Hilbers
    EMBO Journal 16 (1997) 3685-3692
  • RNA aptamers
    H.A. Heus
    Nature Structural Biology 4 (1997) 597-600
  • Heteronuclear scalar couplings in the bases and sugar rings of nucleic acids: Their determination and application in assignment and conformational analysis
    J.H. Ippel, S.S. Wijmenga, R. de Jong, H.A. Heus, C.W. Hilbers, E. de Vroom, G.A. van der Marel and J.H. van Boom
    Magnetic Resonance In Chemistry 34 (1996) S156-S176
  • Unambiguous structure characterization of a DNA-RNA triple helix by N-15- and C-13-filtered NOESY spectroscopy
    M.J.P. van Dongen, H.A. Heus, S.S. Wijmenga, G.A. van der Marel, J.H. van Boom and C.W. Hilbers
    Biochemistry 35 (1996) 1733-1739
  • A network of heterogeneous hydrogen bonds in GNRA tetraloops
    F.M. Jucker, H.A. Heus, P.F. Yip, E.H.M. Moors and A. Pardi
    Journal Of Molecular Biology 264 (1996) 968-980
  • Sequential Backbone Assignment Of Uniformly C-13-Labeled Rnas By A 2-Dimensional P(CC)H-Tocsy Triple-Resonance Nmr Experiment
    S.S. Wijmenga, H.A. Heus, H.A.E. Leeuw, H. Hoppe, M. Van der graaf and C.W. Hilbers
    Journal Of Biomolecular NMR 5 (1995) 82-86
  • Irradiated (15N)DNA as an internal standard for analysis of base-oxidized DNA constituents by isotope dilution mass spectrometry
    A.J. Teixeira, J.C. Klein, H.A. Heus and A.P. de Jong
    Analytical Chemistry 67 (1995) 399-404
  • The hairpin elements of nucleic acid structure: DNA and RNA Folding
    C.W. Hilbers, H.A. Heus, M.J.P. van Dongen, and S.S. Wijmenga 
    In Nucleic Acids and Molecular Biology, F. Eckstein and D.M.J. Lilley (Eds.), Springer Verlag, Berlin-Heidelberg. Vol. 8, 56 (1994)
  • Sequential Backbone Assignment In C-13-Labeled RNA Via Through-Bond Coherence Transfer Using 3-Dimensional Triple-Resonance Spectroscopy (H-1, C-13, P-31) And 2-Dimensional Hetero TOCSY
    H.A. Heus, S.S. Wijmenga, F.J.M. van de Ven and C.W. Hilbers
    Journal Of The American Chemical Society 116 (1994) 4983-4984
  • Assignment Strategies And Analysis Of Cross-Peak Patterns And Intensities In The 3-Dimensional Homonuclear TOCSY-Noesy Of RNA
    S.S. Wijmenga, H.A. Heus, B. Werten, G.A. van der Marel, J.H. van Boom and C.W. Hilbers
    Journal Of Magnetic Resonance Series B 103 (1994) 134-141
  • Through bond sugar-phosphate backbone assignment in 13C-labeled RNA by triple resonance 1H, 13C, and 31P NMR spectroscopy
    S.S. Wijmenga, H.A. Heus, F.J.M. van de Ven and C.W. Hilbers
    In NMR of Biological Macromolecules, NATO ASI Series, vol. H87, C.I. Stassinopoulou (Ed.), Springer Verlag, Berlin-Heidelberg, 304 (1994).
  • Structural Features That Give Rise To The Unusual Stability Of RNA Hairpins Containing GNRA Loops
    H.A. Heus and A. Pardi
    Science 253 (1991) 191-194
  • Novel H-1 Nuclear-Magnetic-Resonance Assignment Procedure For RNA Duplexes
    H.A. Heus and A. Pardi
    Journal Of The American Chemical Society 113 (1991) 4360-4361
  • Nuclear-Magnetic-Resonance Studies Of The Hammerhead Ribozyme Domain - Secondary Structure Formation And Magnesium-Ion Dependence
    H.A. Heus and A. Pardi
    Journal Of Molecular Biology 217 (1991) 113-124
  • Is There A Special Function For U-G Base-Pairs In Ribosomal-RNA
    P.H. van Knippenberg, L.J. Formenoy and H.A. Heus
    Biochimica Et Biophysica Acta 1050 (1990) 14-17
  • Conformational And Thermodynamic Effects Of Naturally-Occurring Base Methylations In A Ribosomal-RNA Hairpin Of Bacillus-Stearothermophilus
    H.A. Heus, L.J. Formenoy and P.H. van Knippenberg
    European Journal Of Biochemistry 188 (1990) 275-281
  • Sequence-Dependent Structural Variations Of Hammerhead RNA Enzymes
    H.A. Heus, O.C. Uhlenbeck and A. Pardi
    Nucleic Acids Research 18 (1990) 1103-1108
  • Isolation and characterization of colicin fragments of bacterial 16S ribosomal RNA
    P.H. van Knippenberg and H.A. Heus
    In Methods in Enzymology (K.Moldave and H.F. Noller, Eds.), Volume 164 (1988)

  • The 3'-terminal colicin fragment of Escherichia coli 16S ribosomal RNA. Conformational details revealed by enzymic and chemical probing.
    H.A. Heus and P.H. van Knippenberg
    J. Biomol. Structures and Dynamics (1988), 5, 951-963

  • Conformation and dynamics of a conserved stem-loop structure in bacterial 16S ribosomal RNA. Implications for function
    P.H. van Knippenberg and H.A. Heus
    In Structure and Expression (R.H. Sarma and M.H. Sarma, Eds.), Volume 7: From Proteins to Ribosomes, 229-237 (1988)

  • Circular dichroism and 500 MHz proton magnetic resonance studies of the interaction of Escherichia coli translational initiator factor 3 protein with the 16S ribosomal 3' colicin fragment.
    Wickstroem, H.A. Heus, C.A.G. Haasnoot and P.H. van Knippenberg
    Biochemistry (1986). 25, 2770-2777

  • Structure, function and evolution of the 3' ends of small ribosomal subunit RNA
    P.H. van Knippenberg, H.A. Heus and C.P.J.J. van Buul
    In Gene Manipulation and Expression (R.E. Glass and J. Spizek Eds.), Beckenham, UK (1985).

  • Phylogeny of the conserved 3'-terminal structure of the RNA of small ribosomal subunits
    P.H. van Knippenberg, J.M.A. van Kimmenade and H.A. Heus
    Nucleic Acids Res. (1984), 12, 2595-604

  • High resolution proton magnetic resonance studies of the 3'-terminal colicin fragment of 16S ribosomal RNA from Escherichia coli.: Assignment of imino proton resonances by Nuclear Overhauser effect experiments and the influence of adenine dimethylation on the hairpin conformation
    H.A. Heus, J.M.A. van Kimmenade, P.H. van Knippenberg, C.A.G. Haasnoot, S.H. de Bruin and C.W. Hilbers
    J. Mol. Biol. (1983), 170, 939-56

  • Calorimetric measurements of the destabilization of a ribosomal RNA hairpin by dimethylation of two adjacent adenosine
    H.A. Heus, J.M.A. van Kimmenade, P.H. van Knippenberg and H.J. Hinz
    Nucleic Acids Res. (1983), 11, 203-10

  • The conformation of a conserved stem-loop structure in ribosomal RNA
    P.H. van Knippenberg and H.A. Heus 
    J. Biomol. Structures and Dynamics (1983), 1, 271-81

  • Destabilization of secondary structure in 16S ribosomal RNA by dimethylation of two adjacent adenosines
    R. van Charldorp, H.A. Heus, P.H. van Knippenberg, J. Joordens, S.H. de Bruin and C.W. Hilbers
    Nucleic Acids Res. (1981), 9, 4413-4422

  • 16S ribosomal RNA of Escherichia coli contains a N2-methylguanosine at 27 nucleotides from the 3' end
    R. van Charldorp, H.A. Heus and P.H. van Knippenberg
    Nucleic Acids Res. (1981), 9, 2717-2725

  • Adenosine dimethylation of 16S ribosomal RNA: Effect of the methyl groups on local conformational stability as deduced from electrophoretic mobility of RNA fragments in denaturing polyacrylamide gels
    R. van Charldorp, H.A. Heus and P.H. van Knippenberg
    Nucleic Acids Res. (1981), 9, 267-275

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