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EPAN: Experimental Psychopathology and Affective Neuroscience

part of EPT

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We study emotion regulation and decision making in healthy individuals and in a wide range of psychopathologies, including their development. We apply several neuroimaging techniques combined with pharmacological interventions and psychophysiological assessments to improve mechanistic understanding of how people regulate automatic action tendencies as well as instrumental approach-avoidance decisions.

Main Projects and funding:

  • Decisions under threat. How can we model and optimize decisions under threat in health and social anxiety? (DARE2APPROACH: ERC-Consolidator).

  • Dynamic Modelling of resilience. Within a large European consortium we aim to test the dynamics of stress-resilience (Dynamore: EU Horizon2020).

  • Police in Action. Can we predict development of post-traumatic stress-symptoms in police officers? Check out this prospective study (NWO-VICI).

  • Enhancing decisions under stress through VR-based biofeedback training (BIOCHILL: NWO-Brain & Cognition).

  • Nijmegen Longitudinal Study. With Developmental Psychology, we study the effects of early and later life events on brain development (ERC-StG).

  • Using brain stimulation to alleviate fear. We use tACS and pioneer with ultrasound stimulation within the national (INTENSE: NWO-Crossover).

Selected publications (past 5 years):

  1. Hutschemaekers MHM, de Kleine RA, Davis ML, Kampman M, Smits JAJ, Roelofs K. Endogenous testosterone levels predict symptom reduction with exposure therapy in social anxiety disorder. Psychoneuroendocrinology, 115:104612
  2. Kaldewaij R, Koch SBJ, Zhang W, Hashemi MM, Klumpers F, Roelofs K. Frontal Control Over Automatic Emotional Action Tendencies Predicts Acute Stress Responsivity. Biol Psychiatry CNII, 4(11):975-983.
  3. Bramson B, Folloni D, Verhagen L, Hartogsveld B, Mars RB, Toni I, Roelofs K. 2020. Human Lateral Frontal Pole Contributes to Control over Emotional Approach-Avoidance Actions. J Neurosci. 40(14):2925-2934.
  4. Schipper P, ea Klumpers F, Hermans EJ, Roelofs K, Henckens MJAG, Homberg JR. The association between serotonin transporter availability and the neural correlates of fear bradycardia (2019). 116(51):25941-25947
  5. Hashemi MM, Gladwin TE, de Valk NM, Zhang W, Kaldewaij R, van Ast V, Koch SBJ, Klumpers F,Roelofs K. (2019). Neural Dynamics of Shooting Decisions and the Switch from Freeze to Fight. Nature Sci Rep.9(1):4240.
  6. Ikink I, Engelmann JB, van den Bos W, Roelofs K, Figner B. (2018). Time ambiguity during intertemporal decision-making is aversive, impacting choice and neural value coding. 185:236-244.
  7. Kalisch R, ea, Roelofs K, ea, Kleim B, International Resilience Allliance (intresa). (2017). The resilience framework as a strategy to combat stress-related disorders. Nature human Behavior. 1-7.
  8. Tyborowska A, Volman I, Smeekens S, Toni I, Roelofs K. 2016. Testosterone during Puberty Shifts Emotional Control from Pulvinar to Anterior Prefrontal Cortex. J Neurosci. 36(23):6156-64.
  9. Ly V, von Borries AK, Brazil IA, Bulten BH, Cools R, Roelofs K. 2016. Reduced Transfer of Affective Value to Instrumental Behavior in Violent Offenders. J Abnorm Psychol, 125(5):657-63.
  10. Lojowska M, Gladwin TE, Hermans EJ, Roelofs K. (2015). Freezing promotes perception of coarse visual features. J Exp Psychol Gen. 144(6):1080-8.

Leader of the research group

Karin Roelofs

Prof. dr. K. Roelofs

31 (0)24 36 120 04
Room number: 03.390

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Lab members