Donders Institute for Brain, Cognition and Behaviour
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Theme 2: Perception, Action and Control

Chronic fatigue

For most people, fatigue is a ‘normal’ and sometimes pleasant state that is experienced regularly.Fatigue becomes a symptom when it is severe, chronic, and interfering with daily live. Chronic fatigue, which is highly prevalent, can be the result of a chronic illness. When a somatic explanation is lacking, we sometimes speak of chronic fatigue syndrome (CFS). I study chronic fatigue in both chronic illness and in CFS. My research focuses on:

- Possible determinants of chronic fatigue;

- Development and implementation of cognitive behavioural interventions;

- Study of the mechanisms of change of effective interventions.

Name: Dr. Hans Knoop
Telephone: 024-3655366
Fax: 024-3610044
Visiting address:

Expert centre for chronic fatigue
Department of Medical Psychology, HP 916
Radboud University Nijmegen Medical Centre
Reinier Postlaan 4
6525 GC Nijmegen
The Netherlands

Postal address: Department of Medical Psychology, HP 916
Radboud University Nijmegen Medical Centre
P.O. Box 9101
6500 HB Nijmegen
The Netherlands

Key publications
  1. Goedendorp MM, Tack CJ, Steggink E, Bloot L,Bazelmans E, Knoop H. Chronic fatigue in type 1diabetes: highly prevalent but not explained by hyperglycemia or glucose variability. Diabetes Care 2014;37:73-80.
  1. Knoop H, van Kessel K, Moss-Morris R. Which cognitions and behaviours mediate the positive effect of cognitive behavioural therapy on fatigue in patients with multiple sclerosis? Psychol Med.2012;42:205-13.
  1. Tummers M, Knoop H, van Dam A, Bleijenberg G.Implementing a minimal intervention for chronic fatigue syndrome in a mental health centre: a randomized controlled trial. Psychol Med. 2012;42:2205-15.
  1. Wiborg JF, Knoop H, Stulemeijer M, Prins JB, Bleijenberg G.How does cognitive behavior therapy reduce fatigue in patients with chronic fatigue syndrome? The role of physical activity. Psychol Med. 2010;40:1281-7.
  1. Tummers M, Knoop H, Bleijenberg G. Effectiveness of stepped care for chronic fatigue syndrome: a randomized noninferiority trial. J Consult Clin Psychol 2010;78(5):724-31.
  1. Heins MJ, Knoop H, Prins JB, Stulemeijer M, van der Meer JW, Bleijenberg G. Possible detrimental effects of cognitive behaviour therapy for chronic fatigue syndrome. Psychother Psychosom 2010;79:249-56.

Back to:
Research Theme 2:
Perception, Action and Decision-making

Research Group
Chronic fatigue

Junior Principal Investigator
Dr. J.A. Knoop

Group members

Stephanie Nikolaus ECCF
Marieke Gielissen ECCF
Marieke van der Schaaf ECCF

PhD students
Harriet Abrahams
Kees Okkersen
Margreet Worm-Smeitink