Donders Institute for Brain, Cognition and Behaviour
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Theme 2: Perception, Action and Control

Developmental Neuropsychiatry

Donders-ACTION-CONTROL-screen thema 2The aim of our research is to determine the cognitive, and functional and structural neural phenotypes of neuropsychiatric disorders (ADHD, autism, dyslexia, aggression-related disorders, substance use); (2) identify the genetic and environmental causes of these disorders and examine to which extent and how genetic and environmental factors interact; (3) determine the functional consequences of these genetic and environmental causes at the neural, cellular and molecular level; (4) develop, test and validate animal models for these neuropsychiatric disorders; (5) within a translational neuroscience framework, examine these neural phenotypes and genetic and environmental factors in closely matched animal and human studies; (6) adopt a developmental perspective across the lifespan; (7) identify new molecular targets and new mechanisms for treatment and prevention of these disorders; (8) examine the effects of interventions on the clinical phenotype and on the cognitive and neural phenotypes, in particular pharmacological and other neurobiological treatments; and (9) to develop effective and clinically feasible methods for screening, early identification and diagnosis of these disorders.

Name: Jan Buitelaar
Telephone: 024-3610750
Fax: 024-3610989
Visiting address:

Department of Cognitive Neuroscience
Radboud University Nijmegen Medical Centre, Trigon building, Route 204
Kapittelweg 29
6525 EN Nijmegen
The Netherlands

Postal address: Department of Cognitive Neuroscience 
Radboud University Nijmegen Medical Centre
P.O. Box 9101 / 205
6500 HB Nijmegen
The Netherlands

IMI EU EU-AIMS. This is a large program built on private-public partnership to identify new molecular targets for treatment of autism, develop new outcome measures, improve clinical trials methodology, and improve and harmonize the clinical infrastructure for autism research.

NeuroIMAGE is a longitudinal integrated DNA x MRI x Cognition study of ADHD probands and their siblings and controls and their siblings.

BOA (Biological Origins of Autism) project that studies the neural, cognitive and genetic factors involved in the overlap between ADHD and autism.

EU Horizon2020 BRAINVIEW is a Marie-Curie training network program aiming to identify the cognitive, behavioural and neural mechanisms that underlie and precede the clinical manifestations of autism and ADHD in babies

EU Horizon2020 MiND is a Marie-Curie training network program aiming to identify the cognitive, behavioural, microbiome and neural mechanisms that underlie the association between autism and ADHD

EU H​orizon2020 Eat2beNICE aims to identify nutrition and lifestyle factors that influence severe impulsivity/compulsivity in males and females across the lifespan, characterize their etiologic paths and test interventions.

Key grants and prizes

2019 - Horizon2020 grant “Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy”(CANDY). PI and coordinator.​

2019 - Horizon2020 Marie Sklodowska-Curie ETN grant “Developmental studies to advance our understanding of social brain development (SAPIENS)”. Co-applicant.

2019 - Horizon2020 grant “Prevention and Remediation of Insulin Multimorbidity in Europe (PRIME). Co-applicant.

2018 – Horizon2020 Innovative Medicines Initiative (IMI) grant “Autism Innovative Medicine Studies – 2 – Trials (AIMS-2-TRIALS)” Co-applicant.

2017 - Horizon2020 grant “Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours (Eat2beNICE)”. Co-applicant.

2015 - Horizon2020 Marie Sklodowska-Curie ETN grant “Integrated view on disruptions of early brain development (BRAINVIEW). PI/coordinator. 
More information

Key publications

  • Marquand AF, Kia SM, Zabihi M, Wolfers T, Buitelaar JK, Beckmann CF. Conceptualizing mental disorders as deviations from normative functioning. Mol Psychiatry. 2019 Jun 14. PMID: 31201374.

  • Matthijssen AM, Dietrich A, Bierens M, Kleine Deters R, van de Loo-Neus GHH, van den Hoofdakker BJ, Buitelaar JK, Hoekstra PJ. Continued Benefits of Methylphenidate in ADHD After 2 Years in Clinical Practice: A Randomized Placebo-Controlled Discontinuation Study. Am J Psychiatry. 2019 May 21:appiajp201918111296. PMID: 31109200.

  • van Rooij D, Anagnostou E, Arango C, Auzias G, Behrmann M, Busatto GF, Calderoni S, Daly E, Deruelle C, Di Martino A, Dinstein I, Duran FLS, Durston S, Ecker C, Fair D, Fedor J, Fitzgerald J, Freitag CM, Gallagher L, Gori I, Haar S, Hoekstra L, Jahanshad N, Jalbrzikowski M, Janssen J, Lerch J, Luna B, MartinhoMM, McGrath J, Muratori F, Murphy CM, Murphy DGM, O'Hearn K, Oranje B, Parellada M, Retico A, Rosa P, Rubia K, Shook D, Taylor M, Thompson PM, Tosetti M, Wallace GL, Zhou F, Buitelaar JK. Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group. Am J Psychiatry. 2018 Apr 1;175(4):359-369. PMID: 29145754;

  • Wolfers T, Floris DL, Dinga R, van Rooij D, Isakoglou C, Kia SM, Zabihi M, Llera A, Chowdanayaka R, Kumar VJ, Peng H, Laidi C, Batalle D, Dimitrova R, Charman T, Loth E, Lai MC, Jones E, Baumeister S, Moessnang C, Banaschewski T, Ecker C, Dumas G, O'Muircheartaigh J, Murphy D, Buitelaar JK, Marquand AF, Beckmann CF. From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder. Neurosci Biobehav Rev. 2019 Sep;104:240-254. PMID: 31330196.

  • Oldehinkel M, Mennes M, Marquand A, Charman T, Tillmann J, Ecker C, Dell'Acqua F, Brandeis D, Banaschewski T, Baumeister S, Moessnang C, Baron-Cohen S, Holt R, Bölte S, Durston S, Kundu P, Lombardo MV, Spooren W, Loth E, Murphy DGM, Beckmann CF, Buitelaar JK; EU-AIMS LEAP group. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Mar;4(3):260-270. PMID: 30711508.

  • Buitelaar is on the list of the Highly Cited Scientists (that is among the top 1% of the most often cited scientists worldwide for the field of psychiatry/psychology) according to Clavirate Analytics (2017 - ).

update SEPT 19

Back to:
Theme 2:
Perception, Action and Control

Research Group
Developmental Neuropsychiatry

Principal Investigator
Prof. dr. J.K. Buitelaar

Group members
Senior researchers

Martine van Dongen
Jeffrey Glennon
Wouter Groen
Iris Oosterling
Dorine Slaats


Giorgia Bussu
Jill Naaijen
Daan van Rooij

PhD candidates

Karin Beuker
Margreet Bierens
Annick Bosch
Ella Bosch
Sarita van Dam
Josi Driessen
Sabrina Hanswijk
Sabrina van Heukelum
Shahrzad Ilbegi
Iva Ilioska
Renee Kleine-Deters
Manon de Korte
Tristan Looden
Cecilia Mazzetti
Ting Mei
Floriana Mogavera
Thaira Openneer
Maria Paraskevopoulu
Sammy Roording
Hyun Ruisch
Gulhan Saracaydin
Gido Schoenacker
Nienke Siebelink
Iris Smeekens
Michelle Snijder
Tammo Viering
Ilse van de Vondelvoort
Francesca Waddington
Emma Ward
Joanna Widomska
Dan Wu

EL update SEP 19