Donders Institute for Brain, Cognition and Behaviour
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Theme 2: Perception, Action and Control

Multifactorial eye diseases

The main goals of our research are to understand the molecular disease mechanisms of common forms of vision loss, to determine which molecular factors can influence response to therapy, and to stratify patients for the most optimal therapy based on their molecular profile. Our research focuses on common diseases of the retina, including age-related macular degeneration (AMD), central serous retinopathy and retinal detachment. By better understanding the molecular background of these diseases we aim to improve patient care towards personal needs (personalized healthcare).

Current research projects include a VICI Innovational Research Award from the Netherlands Organization for Scientific Research, in which we will identify biomarkers for patient stratification, and will model the disease using an organ-on-a-chip model for AMD. In other projects we are searching for (molecular) biomarkers for disease progression in AMD, and we are investigating the role of the complement system in AMD. We are also performing genetic studies for retinal detachment.

Name: A. I. den Hollander
Telephone: 024-3610402
Visiting address:

Department of Ophthalmology / Route 409
Geert Grooteplein Zuid 10
6525 GA Nijmegen
The Netherlands

Postal address:
Key grants and prizes
  • VICI Innovational Research Award, Netherlands Organization for Scientific Research, 2017 (Anneke den Hollander)
  • ERC Proof of Concept Grant, European Research Council, 2017 (Anneke den Hollander)
  • Cogan Award, Association for Research in Vision and Ophthalmology (ARVO), 2015 (Anneke den Hollander)
  • Radboud Science Award, 2014  (Anneke den Hollander)
  • Pfizer Ophthalmics Carl Camras Translational Research Award, ARVO Foundation for Eye Research, 2013 (Anneke den Hollander)
  • Global Ophthalmology Award, Bayer, 2013 (Anneke den Hollander)
  • ERC Starting Grant, European Research Council, 2012 (Anneke den Hollander)



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Research Theme 2:
Perception, Action and Decision-making

Research Group
Sensory Disorders - Retinal Dystrophies

Principal Investigator
Prof. Dr. A.I. den Hollander

Group members at the Department of Ophthalmology:

Carel Hoyng

Laura Lores de Motta
Giuliana Gagliardi

PhD students
Erkin Acar
Anita de Breuk
Birgit Govers
Tom Heesterbeek
Sarah de Jong
Susette Lauwen 
Elja Louer (Department of Physiology)
Manon Peeters (Department of Genetics)

Research technicians
Bjorn Bakker
Louet Koolen