Multifactorial eye diseases
The main goals of our research are to understand the molecular disease mechanisms of common forms of vision loss, to determine which molecular factors can influence response to therapy, and to stratify patients for the most optimal therapy based on their molecular profile. Our research focuses on common diseases of the retina, including age-related macular degeneration (AMD), central serous retinopathy and retinal detachment. By better understanding the molecular background of these diseases we aim to improve patient care towards personal needs (personalized healthcare).
Current research projects include a VICI Innovational Research Award from the Netherlands Organization for Scientific Research, in which we will identify biomarkers for patient stratification, and will model the disease using an organ-on-a-chip model for AMD. In other projects we are searching for (molecular) biomarkers for disease progression in AMD, and we are investigating the role of the complement system in AMD. We are also performing genetic studies for retinal detachment.
|Name:||A. I. den Hollander|
Department of Ophthalmology / Route 409
|Key grants and prizes|
Sensory Disorders - Retinal Dystrophies
Prof. Dr. A.I. den Hollander
Group members at the Department of Ophthalmology:
Laura Lores de Motta
Anita de Breuk
Sarah de Jong
Elja Louer (Department of Physiology)
Manon Peeters (Department of Genetics)