Donders Institute for Brain, Cognition and Behaviour
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Theme 2: Perception, Action and Control

Predictive Brain

Prediction and AttentionPerception and decision-making are not automatic processes, but strongly shaped by internal brain states, which incorporate our goals, attention, expectations, and knowledge about the world.

The mechanisms by which these “top-down factors” affect perception, cognition, and behavior are still largely unknown. Where do the neuronal top-down signals come from? How do they change communication between sensory and decision-related brain regions? And how do these factors affect our perception and decision-making? These questions are the focus of investigation of our group. We use a combination of behavioural and neuroimaging methods (MEG, fMRI, TMS) in healthy volunteers to examine how percepts and decisions are shaped by what we expect (prediction) and deem relevant (attention).

Name: Floris de Lange
Telephone: 024-3610658
Fax: 024-3610989
Visiting address: Donders Centre for Cognitive Neuroimaging
Kapittelweg 29
6525 EN Nijmegen
The Netherlands
Postal address: Donders Centre for Cognitive Neuroimaging
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
Key grants and prizes
  • Heineken Young Scientist Award for Cognitive Science 2012 (Royal Dutch Academy of Sciences, KNAW)
  • Biomag Young Investigator Award 2012 (Biomag Organization)
  • Open Competition Grant (Netherlands Science Foundation, NWO-MaGW) 2011
  • VENI Grant (Netherlands Science Foundation, NWO-MaGW) 2009
  • Rubicon Grant (Netherlands Science Foundation, NWO-MaGW) 2007
Key publications
  • de Lange FP, Rahnev D, Donner TH, Lau HC (2013). Pre-stimulus oscillatory activity over motor cortex reflects perceptual expectations. Journal of Neuroscience, in press
  • de Lange FP, van Gaal S, Lamme VA, Dehaene S (2011). How awareness changes the relative weights of evidence during human decision making. PLoS Biology, 9(11): e1001203. pdf
  • Kok P, Jehee JFM, de Lange FP (2012). Less is more: Expectation sharpens representations in the primary visual cortex. Neuron 75, 265-270. pdf
  • Kok P, Rahnev D, Jehee J, Lau HC, de Lange FP (2012). Attention reverses the effect of prediction in silencing sensory signals. Cerebral Cortex 22, 2197-2206. pdf
  • Todorovic A, de Lange FP (2012). Repetition Suppression and Expectation Suppression Are Dissociable in Time in Early Auditory Evoked Fields. Journal of Neuroscience, 32, 13389-95. pdf


Predictive Brain lab