Theme 3: Plasticity and Memory

Neuroanatomy

Donders Institute for Brain, Cognition and Behaviour Tamas Kozicz' research group probes structural and functional correlates
of stress-related neuronal plasticity in the rodent brain and in human post-mortem brain samples.

His group has established a fundamental research line with a strong translational aspect in stress (mal)adaptation and energy metabolism, with a special attention to neuronal mechanisms of sex differences. The outcome of various stress and feeding paradigms as well as adverse early life experience are in his focus by using a highly interdisciplinary approach integrating functional neuroanatomical, behavioral, (epi)genetic and physiological aspects of the action(s) of CRF-family of neuropeptides in in vivo and in vitro model systems.

In addition, his group apply various transgenic and lentivirus mediated rodent models of suboptimal mitochondrial function and depression-like behavior. Kozicz' work is nationally as well as internationally recognized on the biological significance of urocortin 1.

Contact

Name:	Tamas Kozicz
Telephone:	024-3617625
Email:	T.Kozicz@anat.umcn.nl
Visiting address:	Radboud University Medical Centre Department of Anatomy Geert Grooteplein North 2 6525 EZ Nijmegen The Netherlands
Postal address:	Radboud University Medical Centre Department of Anatomy P.O. Box 9101 6500 HB Nijmegen The Netherlands

Key publications

Morava E. and Kozicz T. Economy of stress (mal)adaptation. Neuroscience and Biobehavioral Reviews, 10.1016/j.neubiorev.2013.02.005; Ref NBR1712. IF: 9.67

van der Doelen RH, Homberg JR, Kozicz T. Adaptive fitness; early life adversity improves adult stress coping in heterozygous serotonin transporter knockout rats. Mol Psychiatry, 2013 Jan 15. doi: 10.1038/mp.2012.186. [Epub ahead of print] PubMed PMID: 23319004. IF: 12.99

van Wingen GA, Geuze E, Caan MW, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G. Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. Proc Natl Acad Sci U S A, 2012 Sep 18;109(38):15508-13. IF: 10.47

Spencer SJ, Xu L, Clarke MA, Lemus M, Reichenbach A, Geenen B, Kozicz T and Andrews ZB. Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress. Biol Psychiatry. 2012 Sep 15;72(6):457-65. IF: 9.24

Bloem B, Xu L, Morava E, Faludi G, Palkovits M, Roubos EW, Kozicz T. Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls. Neuropharmacology, 2012 Jan;62(1):297-303. IF: 4.81

Xu L, Scheenen WJ, Leshan RL, Patterson CM, Elias CF, Bouwhuis S, Roubos EW, Myers MG Jr, Kozicz T. Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic edinger-westphal nucleus. Endocrinology, 2011 Mar;152(3):979-88. IF: 4.62

Key grants and prizes

Hayward Foundation; Tulane University Nijmegen (2012-2015); K$ 510; Energy metabolism and stress adaptation

NWO-ALW-Research grant; #819.02.022 (2009-2013); PhD; k€ 288; ‘Serotonin transporter gene polymorphism by adverse life events interaction: an anatomical and behavioural approach towards the understanding of nature-nurture interaction in the psychobiology of depression"; role: PI

EU - Euron Master Programme Neuroscience (2009-2012); PhD for one year ; k€ 62 ; role : PI

EURON/EC-Research grant; Marie Curie Training Fellowship (2007-2008); PhD; k€ 70. Urocortinergic neurons in the Rat Edinger-Westphal nucleus and stress’; role: PI

NWO-Research program/VIDI grant #864.05.008 (2005-2009); PhD; k€ 150; ‘Characterization of a novel candidate central core mechanism in stress adaptation: the Edinger-Westphal urocortin 1 neuronal system’

2001 and 2002 Hungarian State Eotvös Fellowship by the Hungarian Academy of Sciences

1999-2002 Bolyai János Research Scholarship granted by the Hungarian Academy of Sciences

Back to:
Theme 3:
Plasticity and Memory

Research Group
Neuroanatomy

Principal Investigator
Prof.dr. T.L. Kozicz