Preclinical Neuroimaging

Our aim is to investigate animal models of neurological and psychiatric disorders to bring forward disease mechanisms and to test novel therapeutics with a focus on translational neuroimaging technologies. We focus on functional Magnetic Resonance Imaging as the main tool to investigate neuronal-vascular activity and to establish functional connectivity across the whole-brain in healthy and rodent models of brain disorders. Statistical imaging and database mining are used to complement our neuronal network models. We implement genetically-encoded neuromodulatory tools, optogenetics and chemogenetics, to causally manipulate key hub regions of the brain, concurrently with whole-brain functional imaging to elucidate the fundamental role played by vulnerable elements of a neuronal network.

Dr. Joanes Grandjean develops and applies neuroimaging technologies adapted for preclinical research in rodent models of neurological and psychiatric disorders. He is hosted at the Radiology and Nuclear Medicine department and Cognitive Neuroscience department of the Radboud University Medical Center. He is part of the Donders Institute for brain cognition and behaviour and operate laboratories at the Preclinical Imaging Center.

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