The general interest of our research group is to understand the underlying molecular events, leading to changes in synaptic structure and function and how these changes relate to learning and memory.
As a molecular entry point for this research we focus on the functional characterization of genes associated with intellectual disability (ID), a disease characterized by synaptic deficits (synaptopathy). Great progress has been made over recent years towards the identification of ID genes, resulting in a list of more than 400 genes.
A largely remaining challenge, however, is to connect the genetic causes of ID to processes that establish and/or modify neuronal circuit function. Because learning deficit is a constant feature of ID patients, it is tempting to attribute some of ID traits to alterations in synaptic structure and function (synaptopathy). Our current efforts are geared towards understanding how synaptic properties are acquired and change during development.
To this end we are investigating the role Rho GTPase signaling and chromatin remodeling pathways (epigenetics). To gain insight into these pathways we take a multidisciplinary approach that includes: (i) electrophysiological assessment of synaptic transmission (ii) two-photon imaging of neuronal structures (iii) manipulation of proteins of interest in subsets of neurons and (iv) molecular biology techniques to characterize proteins that regulate synaptic development and are involved in cognitive disorders.
|Name:||Nael Nadif Kasri|
|Visiting address:||Department of Cognitive Neuroscience
Radboud University Nijmegen Medical Centre / 855
Geert Grooteplein Zuid 10
6525 EZ Nijmegen
|Postal address:||Department of Cognitive Neuroscience
Radboud University Nijmegen Medical Centre / HP 855
P.O. Box 9101
6500 HB Nijmegen
Plasticity and Memory
N. Nadif Kasri
PhDs (in alphabetical order)
Teun Klein Gunnewiek
Jori van der Raadt
Jon-Ruben van Rhijn
EL update Apr 17
*Open group photo (png, 350 kB)