Donders Institute for Brain, Cognition and Behaviour
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Theme 4: Brain Networks and Neuronal Communication

Clinical Neurophysiology

Donders Institute for Brain, Cognition and BehaviourClinical Neurophysiology is a supporting discipline for functional assessment of brain, nerve and muscle function. The discipline applies various electrophysiological techniques such as EEG, needle- and surface-EMG, evoked potentials and non-invasive brain stimulation (e.g. TMS, tDCS). It also uses ultrasound techniques to study structure of nerves and muscles and the blood flow characteristics towards and in the brain.

The research group develops instruments and procedures to improve the clinical goals, but also applies these developments in basic neuroscientific questions in health and disease. The group manages a laboratory for TMS techniques at two locations (DCN-neurology, DCCN). A system for so-called high density EMG was developed, giving insight in the mechanisms driving individual muscles much more precisely (e.g. motoneuron firing patterns) than conventional EMG techniques do.

Combining central nervous (MEG, EEG) and peripheral (EMG) electrophysiological techniques with brain stimulation and fMRI, allows disentangling network function and coupling in the motor system, also in neurological diseases (e.g Parkinson’s disease). Mathematical modeling of ion current flow in extracellular media, of pathological loss of peripheral nerve fibres and of characteristics of corticospinal coupling is part of the expertise. The group is imbedded in Theme 4, but has also connection to Theme 2.

Name: Dick Stegeman
Visiting address: Department of Neurology
Radboud University Nijmegen Medical Centre
Reinier Postlaan 4
6525 GC Nijmegen
The Netherlands
Postal address: Department of Neurology
Radboud University Nijmegen Medical Centre
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
Key grants and prizes
  • Sumientra Rampersad for her presentation in the Theme 4 meeting, December 2012.
Key publications
  • Munneke MAM, Rongen JJ, Schelhaas HJ, Overeem S, Zwarts MJ, Stegeman DF. Cumulative effect of 5 day theta burst stimulation on cortical excitability in ALS. Muscle & Nerve, in press
  • Rampersad S, Stegeman D, Oostendorp T. Single-layer skull approximations perform well in transcranial direct current stimulation modeling. IEEE Trans Neural Syst Rehabil Eng. 2012 Jul 27. [Epub ahead of print]
  • Stegeman DF, van de Ven WJ, van Elswijk GA, Oostenveld R, Kleine BU. The alpha-motoneuron pool as transmitter of rhythmicities in cortical motor drive. Clin Neurophysiol. 2010 Oct;121(10):1633-42.
  • Kleine BU, Stegeman DF, Schelhaas HJ, Zwarts MJ. Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin. Neurology. 2008 Jan 29;70(5):353-9.
  • van Elswijk G, Kleine BU, Overeem S, Stegeman DF. Expectancy induces dynamic modulation of corticospinal excitability. J Cogn Neurosci. 2007 Jan;19(1):121-31.

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Theme 4:
Natural Computing & Neurotechnology

Research Group
Clinical Neurophysiology

Principal Investigator
Prof.dr. Dick Stegeman

Group members
Arno Janssen
Moniek Munneke
Sumientra Rampersad
Mark Massa