Theme 4: Brain Networks and Neuronal Communication

MR Structural Quantitative Imaging

Structural magnetic resonance imaging can give you beautiful images of the brain… but do they don’t tell us much about the tissue properties of a given brain region.

Our group focuses on creating new strategies to obtain both high quality and informative images that take full advantage of the interaction of the used magnetic fields (static and radiofrequency) with the tissues electro-magnetic tissue properties.

This is done by: developing new sequences for in vivo imaging free artifacts, developing biophysical tissue models and strategies to transform the obtained imaging data into quantitative tissue information.

We contribute to the understanding of the mechanisms that give rise to the observed relaxation and devise protocols that could give clinicians and neuroscientists an increased capability to measure tissue property maturation, degeneration and viability. And because we like our subjects to enjoy their scanning sessions, we would like to do this as fast as possible!

Contact
Name:	José P. Marques
Telephone:	024-3668491
Email:	j.marques@donders.ru.nl
Fax:	024-3610989
Visiting address:	Donders Centre for Cognitive Neuroimaging Kapittelweg 29 6525 EN Nijmegen The Netherlands
Postal address:	Donders Centre for Cognitive Neuroimaging P.O. Box 9101 6500 HB Nijmegen The Netherlands

Key grants and prizes

2019-2022 Metabolic Anatomic and Physiologic MRI Endogenously - Health Holland

2017-2021 Thinking Inside the Voxel – what can magnetic fields tell us about brain white matter properties NWOi –FOM

2015-2017 Advanced high-field MR imaging and quantitative analysis for segmentation of the thalamic nuclei -Swiss National Foundation

2011-2015 Susceptibility Mapping of the Human Brain – Swiss National Foundation

Key publications

Chan, K, Norris, D., Marques,J.P. (2018). Structure tensor informed fibre tractography at 3T, Human Brain Mapping.

Marques, J.P., Khabipova, D., Gruetter, R. (2017). Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R1, R2* and magnetic susceptibility. NeuroImage, 147, 152–163.

Marques, J.P., Norris, D.G., 2018. How to choose the right MR sequence for your research question at 7 T and above?Neuroimage, 168, 119-140.

Marques, J.P., Kober, T., Krueger, G., van der Zwaag, W., Van de Moortele, P.-F., Gruetter, R. (2010). MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field.NeuroImage, 49/2, 1271–1281.

Marques, J.P., Bowtell, R. (2005). Application of a fourier-based method for rapid calculation of field inhomogeneity due to spatial variation of magnetic susceptibility. Concepts in Magnetic Resonance Part B (Magnetic Resonance Engineering), 25B(1), 65–78.

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Theme 4:
Natural Computing & Neurotechnology

Research Group
MR Structural Quantitative Imaging

Principal Investigator
José P. Marques

Group members

Postdoc
Renaud Hedouin