Donders Institute for Brain, Cognition and Behaviour
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Theme 4: Brain Networks and Neuronal Communication


Donders Institute for Brain, Cognition and BehaviourThe Tiesinga group in the Neuroinformatics department currently has three research themes. First, to understand processing of sensory information in the brain, and the modulation thereof by cognitive factors, at the level of networks of spiking neurons. This is accomplished by building biophysical models ranging in size from single neurons up to many hundred thousands of neurons.

Second, to develop methods to analyze multivariate data recorded from the brain in order to quantify communication between cortical networks. This is accomplished by determining robust ways of determining the Granger causality and applying information theoretical approaches. Third, to test theoretical hypotheses at the cortical microcircuit level by recording from cultures.

Within the department, Dr. Francesco Battaglia uses a systems neuroscience approach to study how the interaction between brain areas subserves memory and other cognitive processes.

Name: Paul Tiesinga
Telephone: 024-3652232
Visiting address: Department of Neuroinformatics
Faculty of Science
Heyendaalseweg 135
6525 AJ Nijmegen
The Netherlands
Postal address: Department of Neuroinformatics
Faculty of Science
P.O. Box 9010
Internal mailbox 66
6500 GL Nijmegen
The Netherlands
Key grants and prizes
  • Neuroseeker FET IP
  • Human Brain Project FET Flagship
  • eScience project Biomarker Boosting (NWO)
Key publications
  • Memmesheimer, R.M. & Timme, M. (2012) Non-additive coupling enables propagation of synchronous spiking activity in purely random networks. PLoS Comput Biol, 8, e1002384
  • Toups, J.V., Fellous, J.M., Thomas, P.J., Sejnowski, T.J. & Tiesinga, P.H. (2012) Multiple spike time patterns occur at bifurcation points of membrane potential dynamics. PLoS Comput Biol, 8, e1002615
  • Tiesinga, P.H. (2012) Motifs in health and disease: the promise of circuit interrogation by optogenetics. Eur J Neurosci, 36, 2260-2272
  • Memmesheimer, R.M. (2010) Quantitative prediction of intermittent high-frequency oscillations in neural networks with supralinear dendritic interactions. Proc Natl Acad Sci U S A, 107, 11092-11097
  • P.H.E. Tiesinga and T.J. Sejnowski, Cortical Enlightenment: Are Attentional Gamma Oscillations Driven by ING or PING? Neuron 63 (2009) 727-732


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Theme 4:
Natural Computing & Neurotechnology

Research Group

Principal Investigator
prof. dr. Paul Tiesinga

Special appointments
prof.dr. Simon Fisher

Group members:

Postdocs Rembrandt Bakker
dr. Nestor Timonidis

Francesca Abela
Charl Linssen
Marije ter Wal
Xiaochen Zhao

(Update January 2023)