Donders Institute for Brain, Cognition and Behaviour
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Theme 4: Brain Networks and Neuronal Communication

Neuronal Oscillations

Neuronal OscillationsThe main goal of the 'Neuronal Oscillations' research group is to understand how oscillatory activity shapes the functional architecture of the working brain during cognitive processing.

While modulations alpha band oscillations (8-13 Hz) reflect anticipatory top-down modulation, bottom-up processing is reflected by gamma band synchronization (30-100 Hz). Specifically, the core hypothesize states that neuronal communication is gated by the inhibition of task-irrelevant regions, thus routing information to task-relevant regions. The functional inhibition is reflected by alpha band oscillations.

From a physiological perspective, the alpha oscillations provide pulsed inhibition reducing the processing capabilities of a given area. Active processing is achieved by neuronal synchronization in the gamma band which is phasically modulated by the alpha oscillations. According to this framework the brain can be studied as a network by investigating cross-frequency interactions between gamma and alpha activity.

The research tools applied by the group include computational modeling, MEG, EEG combined with fMRI, EEG combined with TMS and intracranial recordings. These tools are applied to investigate and interpret data from humans and animals performing attention and memory tasks.

Contact
Name: Ole Jensen
Telephone: 024-3610884
Email: ole.jensen@donders.ru.nl
Fax: 024-3610989
Visiting address: Donders Centre for Cognitive Neuroimaging
Kapittelweg 29
6525 EN Nijmegen
The Netherlands
Postal address: Donders Centre for Cognitive Neuroimaging
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
Key grants and prizes
  • Mid-Career Achievement Award for Ole Jensen, 13th International Conference on Biomagnetism (2012)
  • Transcranial brain stimulation investigations on the role of oscillatory phase in neuronal processing. Program: Open Competition, NWO, ALW (2012)
  • Bridging the gap between neuronal activity and neuroimaging: a physiologically realistic model. Program: NWO, Open Competition, ALW (2011)
  • Pharmacological modulation of alpha and gamma oscillations: implications for working memory maintenance. Program: NWO, Open Competition, MaGW (2010)
  • How the functional architecture of the working brain is shaped by oscillatory brain activity. Program: VICI, NWO, MaGW (2010)
Key publications
  • Spaak, E., Bonnefond, M., Maier, A., Leopold, D.A..and Jensen, O. (2012) Layer-specific entrainment of gamma-band neural activity by the alpha rhythm in monkey visual cortex. Curr Biol 22:2313-2318
  • Bonnefond, M. and Jensen, O. (2012) Anticipatory adjustment of power and phase of alpha oscillations protects working memory maintenance against distracters. Curr Biol 22:1969-1974.
  • Jensen, O., Bonnefond, M., and VanRullen, R. (2012) An oscillatory mechanism for prioritizing salient unattended stimuli. Trends Cogn Sci 16:200-206
  • Haegens, S., Nácher, V., Luna, R. Romo, R. and Jensen, O. (2011) Alpha oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking. Proc Natl Acad Sci U S A 108:19377-19382.
  • van Dijk, H., Van der Werf, J., Mazaheri, A., Medendorp, W.P., and Jensen, O. (2010) Modulations in oscillatory activity with amplitude asymmetry can produce cognitively relevant event-related responses. Proc Natl Acad Sci U S A 107:900-905.

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Theme 4:
Neural Computation and Neurotechnology

Donders
Research Group
Neuronal Oscillations

Principal Investigator
Prof. Ole Jensen

Group members

Senior researchers
Dr. Mathilde Bonnefond
Prof. Jan van der Eerden

Postdoctoral Researchers
Dr. Saskia Haegens


PhD students
Linda Drijvers
Niels ter Huurne
Maarten Leenders
Lisa Luther
Cecilia Mazzetti


Research assistants
Dr. Iske Bakker


MSc and BSc Students