Donders Institute for Brain, Cognition and Behaviour
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Theme 4: Brain Networks and Neuronal Communication

Neurophysiology of Basal Ganglia-related Movement Disorders

Donders Institute for Brain, Cognition and BehaviourThe role of the basal ganglia in normal movement, as in other domains, is still a matter of controversy. Likewise, motor impairments in neurological movement disorders are poorly understood.

Using electro- and magnetoencephalography we study slow brain potentials and oscillatory activity in motor and cognitive tasks, as a means to elucidate basal ganglia function and basal ganglia pathophysiology of neurological movement disorders. A central theme concerns the role of altered oscillatory activity in basal ganglia-thalamo-cortical circuits. Current work addresses basal ganglia involvement in the selection of movement and timing functions of the basal ganglia. The latter work has an applied component related to cueing in Parkinson’s disease.

Contact
Name: Peter Praamstra
Telephone: 024-3613396
Email: p.praamstra@neuro.umcn.nl
Fax: 024-3541122
Visiting address: Department of Neurology
Radboud University Nijmegen Medical Centre
Reinier Postlaan 4
6525 GC Nijmegen
The Netherlands
Postal address: Donders Centre for Cognitive Neuroimaging
P.O. Box 9101
6500 HB Nijmegen
The Netherlands


Key grants and prizes
  • Movement selection in the parietofrontal cortex: The affordance competition hypothesis (MaGW 2012-2015; collaboration with prof. dr. W.P. Medendorp)
  • Feeling the beat: The neuro-physiology of cueing in Parkinson’s disease (DCN internal grant 2012-2016; collaboration with dr. F.P. de Lange)
Key publications
  • Rawle CJ, Miall RC, Praamstra P. Frontoparietal theta activity supports behavioral decisions in movement-target selection. Front Hum Neurosci. 2012;6:138. Epub 2012 May 18. PubMed PMID: 22629241; PubMed Central PMCID: PMC3355324.
  • Praamstra P, Torney L, Rawle CJ, Miall RC. Misconceptions about mirror-induced motor cortex activation. Cereb Cortex. 2011 Aug;21(8):1935-40. Epub 2011 Jan 12. PubMed PMID: 21228100; PubMed Central PMCID: PMC3138518.
  • Praamstra P, Kourtis D, Nazarpour K. Simultaneous preparation of multiple potential movements: opposing effects of spatial proximity mediated by premotor and parietal cortex. J Neurophysiol. 2009 Oct;102(4):2084-95. Epub 2009 Aug 5. PubMed PMID: 19657085.
  • Van Wijk BC, Daffertshofer A, Roach N, Praamstra P. A role of beta oscillatory synchrony in biasing response competition? Cereb Cortex. 2009 Jun;19(6):1294-302. Epub 2008 Oct 3. PubMed PMID: 18836098.
  • Praamstra P, Pope P. Slow brain potential and oscillatory EEG manifestations of impaired temporal preparation in Parkinson's disease. J Neurophysiol. 2007 Nov;98(5):2848-57. Epub 2007 Aug 29. PubMed PMID: 17728390.

Back to:
Theme 4:
Neural Computation and Neurotechnology

Donders
Research Group
Neurophysiology of Basal Ganglia-related Movement Disorders

Aspiring Principal Investigator
Dr. Peter Praamstra

Group members

Scientific staff
Dr. Tineke Grent-‘t-Jong

PhD
Erik te Woerd
Andrea Loing

Master student
Simone Heideman
Linda Bauer