Donders Institute for Brain, Cognition and Behaviour
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Theme 4: Brain Networks and Neuronal Communication

The Uncertain Systems lab

The Uncertain Systems lab aims to identify the mechanisms by which complex networked systems evolve and behave. Our main objectives are to identify the low-dimensional regularities in these systems so that we can interpret their behaviour, to predict how they will act in their future environment, and to eventually exert control over them.

Of course, doing so is a daunting task. Not only are large-scale system dynamics difficult to identify in general, but our observations of these systems are often sparse, indirect and noisy. Dealing with both this epistemic and aleatoric uncertainty requires the development of new probabilistic models and techniques, which plays a central role in our group. We particularly make use of Bayesian nonparametric methods, which allows us to adjust model complexity on the fly.

We apply our work in several domains, including: network neuroscience, genetics, (human) learning behaviour, and (personalized) healthcare.

Name: Dr. Max Hinne
Visiting address: Donders Centre for Cognition
Thomas van Aquinostraat 4
6525 GD Nijmegen
The Netherlands
Postal address: Donders Centre for Cognition
P.O. Box 9104
6500 HE Nijmegen
The Netherlands
Key grants and prizes
Key publications
  • Dingemans, A. J., Hinne, M., Jansen, S., van Reeuwijk, J., de Leeuw, N., Pfundt, R., ... & de Vries, B. B. (2022). Phenotype based prediction of exome sequencing outcome using machine learning for neurodevelopmental disorders. Genetics in Medicine, 24(3), 645-653.
  • Hinne M, Gronau QF, van den Bergh D, Wagenmakers E-J. A conceptual introduction to Bayesian model averaging. Advances in Methods and Practices in Psychological Science. June 2020:200-215.
  • Hinne M, Meijers A, Bakker R, Tiesinga PHE, Mørup M, et al. (2017) The missing link: Predicting connectomes from noisy and partially observed tract tracing data. PLOS Computational Biology 13(1): e1005374.


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Theme 4:
Natural Computing & Neurotechnology


Research Group
The Uncertain Systems lab

Principal Investigator
Dr. Max Hinne

Group members


  • Fabian Dablander (@UvA)
  • Gelana Khazeeva
  • Lex Dingemans
  • Rick Dijkstra
  • Hester Huijsdens
  • Constantin Börker