ENIGMA stands for: Enhancing Neuro Imaging Genetics Through Meta-Analysis. The ENIGMA Network brings together researchers in imaging genomics to understand brain structure and function based on MRI, DTI, fMRI, and genomewide association scan (GWAS) data. Cognomics contributes to ENIGMA by sharing the BIG dataset and expertise from researchers.
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The International Multicentre persistent ADHD Genetics CollaboraTion (IMpACT) consists of 7 different sites in Europe and the Americas aiming to perform and promote research into the genetics of persistent ADHD. In Nijmegen, we focus on combining neuroimaging and genetics.
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A cohort of several hundred individuals with ADHD and their siblings were followed over time and compared with ‘control’ families. Collected data included semi-structured psychiatric interviews, questionnaires, neuropsychological testing, neuroimaging and DNA-samples. The NeuroIMAGE sample provides a rich resource for the investigation of structure and function of the brain in ADHD and the underlying genetics.
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CoCA (Comorbid Conditions of ADHD) studies the comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety and substance use disorders, and a highly prevalent somatic disease, obesity. CoCA will use well-characterized pre-existing samples to identify genetic and environmental risk factors for the overlap of ADHD, mood/anxiety disorders, SUD, and obesity, and to test whether genetic subgroups with potential prognostic implications can be defined.
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