Donders Institute for Brain, Cognition and Behaviour
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BIG Database

The BIG database consists of brain imaging data, genetic data and results of cognitive tasks and questionnaires of over 3500 healthy adults subjects recruited in the Nijmegen area. Below you will find specific information about the data in the database and which tools were used to process the data.

Brain imaging

Subjects are scanned in either a 1.5T or a 3.0T Siemens MRI scanner in the Donders Centre for Cognitive Neuroimaging. All subjects in BIG undergo a structural MRI scan. To segment the MRI images two software packages are used. DTI data and/or resting state data are available for part of the sample.

  • Anatomical Magnetic Resonance Imaging (MRI) 
    Freesurfer segmentation (ENIGMA protocols)
    FSL segmentation (ENIGMA protocols)
    Voxel Based Morphology (VBM)
  • Diffusor Tensor Imaging (DTI)
  • Resting state imaging scans

Genetic data

Subjects participating in the BIG study are asked to donate saliva. DNA is extracted from the saliva and processed and genotyped. The genetic data available include:

  • Genome wide genotyping for Genome Wide Association Studies (GWAS)
  • Popular Variable Number of Tandem Repeats (VNTR's)
  • Popular Single Nucleotide Polymorphisms (SNP’s, e.g., in 5-HTTPR, BDNF, COMT)
  • Copy Number Variations (CNV's)

BIG data underwent genome-wide genotyping in 3 batches. In batch 1 approximately 1300 individuals were genotyped on the Affymetrix 6.0 genotyping platform, in batch 2 approximately 500 individuals were genotyped on the PsychChip genotyping array, and in batch 3 almost 1000 individuals were genotyped on the OmniExpress genotyping platform.

Online testing iBIG (2009-2018)

Tasks

  • Face location memory task; N=1541
  • Working memory task; (see this reference); N=2048
  • Reversal learning task; (see this reference); N=1807
  • Memory bias task; (see this reference); N=1967

Questionnaires

  • General questions and positive and negative affect schedule (PANAS) (see this reference); N=2211
  • Stressful life events questionnaire (see this reference); N=2069
  • ADHD self-rating questionnaire (see this reference); N=2041

Online testing iBIG1.5 (2014)

A subset of participants that completed iBIG was asked for a follow-up testing session in 2014. 652 participants completed this extra testing session.

Task

  • Social learning task (based on this reference)

Questionnaires

  • Multidimensional scale of perceived social support (see this reference)
  • The sociable and aggressive dominance scale (see this reference)
  • Barratt simplified measure of social status (see this reference)
  • Reading ability in Dutch (READ) questionnaire
  • Alcohol and smoking)
  • Aggression questionnaire (see this reference)
  • Dutch autism questionnaire (see this reference)
  • The Reactive–Proactive Aggression Questionnaire (see this reference)
  • Language problems
  • Handedness
  • Synesthesia
  • Inventory of Callous and Unemotional traits (see this reference)

Online testing iBIG2.1 (2017-2019)

A new version of iBIG was launched in 2017. IBIG2 consists of tasks and questionnaires that overlap with iBIG1 or iBIG1.5, but it also has some new components. About 650 participants (old and new) have completed this test battery.

Tasks

  • Working memory (digit span)
  • Dichotic listening task
  • Dutch LexTALE task (see this reference)
  • Memory bias task; (see this reference)

Questionnaires

  • Adult ADHD Self-Report Scale (ASRS-v1.1.)
  • Synesthesia
  • Dutch autism questionnaire (see this reference)
  • Inventory of Callous and Unemotional traits (see this reference)
  • Stressful life events questionnaire (see this reference)
  • Reading ability in Dutch (READ) questionnaire
  • The Reactive–Proactive Aggression Questionnaire (see this reference)
  • Creative Achievement Questionnaire (see this reference)

Online testing iBIG2.2 (2019)

About 400 participants have completed this test battery.

Tasks

  • Alternative uses test (creativity)
  • Remote associates test (creativity)
  • Face location memory task
  • Reversal learning task
  • Adapted version of Cattell's Culture Fair Intelligence Test (IQ)

Questionnaires

  • Online gaming question
  • Substance use (AUDIT, Fagerstrom, DAST)
  • Childhood Retrospective Perfectionism Questionnaire (CHIRP)
  • Social behaviour questions (UKBiobank)
  • Eysenck Personality Questionnaire (Short version)
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