Donders Institute for Brain, Cognition and Behaviour
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BIG Publications


Brouwer, R.M., Klein, M., Grasby, K.L., Schnack, H.G., Jahanshad, N., Teeuw, J., et al. (2020). Dynamics of Brain Structure and its Genetic Architecture over the Lifespan, Preprint.

Córdova-Palomera, A., van der Meer, D., Kaufmann, T., Bettella, F., Wang, Y., Alnaes, D., et al. (2020). Genetic control of variability in subcortical and intracranial volumes, Molecular Psychiatry Epub.

Dima, D., Papachristou, E., Modabbernia, A., Doucet, G.E., Agartz, I., et al. (2020). Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years, Preprint.

Frangou, S., Modabbernia, A., Doucet, G.E., Papachristou, P., Williams, S.C.R., Agartz, I., et al. (2020). Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years, Preprint.

Grasby, K.L., Jahanshad, N., Painter, J.N., Colodro-Conde, L., Bralten, J., Hibar, D.P., et al. (2020). The genetic architecture of the human cerebral cortex, Science 367.

Guadalupe, T., Kong, X-Z., Akkermans, S.E.A., Fisher, S.E., Francks, C. (2020). Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults, Preprint.

Kong X-Z., Postema, M.C., Guadalupe, T., de Kovel, C., Boedhoe, P.S.W., Hoogman, M., et al. (2020). Mapping brain asymmetry in health and disease through the ENIGMA consortium, Human Brain Mapping Epub.

Sønderby, I.E., Gústafsson, Ó., Doan, N.T., Hibar, D.P., Martin-Brevet, S., Abdellaoui, A., et al. (2020). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia, Molecular Psychiatry 25, 584-602.

van Donkelaar, M.M.J., Hoogman, M., Shumskaya, E., Buitelaar, J.K., Bralten, J., Franke, B. (2020). Monoamine and neuroendocrine gene-sets associate with frustration-based aggression in a gender-specific manner, European Neuropsychopharmacology 30, 75-86.

Wierenga, L.M., Doucet, G.E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T.N., et al. (2020). Greater male than female variability in regional brain structure across the lifespan, Preprint.


Adams, H.H.H., Roshchupkin, G.V., DeCarli, C., Franke, B., Grabe, H.J., Habes, M, et al. (2019). Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings, Alzheimer’s & Dementia 11, 286-290.

Gunz, P., Tilot, A.K., Wittfeld, K., Teumer, A., Shapland, C.Y., van Erp, T.G.M., et al. (2019). Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity, Current Biology 29, 120-127.

Jahanshad, N., Faskowitz, J.I., Roshchupkin, G., Hibar, D., Gutman, B.A., Tustison, N.J., et al. (2019). Multi-site meta-analysis of morphometry, IEEE/ACM Transactions on Computational Biology and Bioinformatics Epub.

Kaufmann, T, van der Meer, D., Doan, N.T., Schwarz, E., Lund, M.J., Agartz, I., et al. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain, Nature Neuroscience 22, 1617-1623.

Satizabal, C.L., Adams, H.H.H., Hibar, D.P., White, C.C., Knol, M.J., Stein, J.L., et al.  (2019). Genetic architecture of subcortical brain structures in 38,851 individuals, Nature Genetics 51, 1624-1636.

Tilot, A.K., Khramtsova, E.A., Grasby, K., Jahanshad, N., Painter, J., Colodro-Conde, L., et al. (2019). The Evolutionary History of Common Genetic Variants Influencing Human Cortical Surface Area, Preprint.

Tilot, A.K., Vino, A., Kucera, K.S., Carmichael, D.A., van den Heuvel, L., den Hoed, J., et al. (2019). Investigating genetic links between grapheme–colour synaesthesia and neuropsychiatric traits, Philosophical transactions of the Royal Society B 374, Epub.

Vollebrecht, M.A., Franke, B., Buitelaar, J.K., Arnold, L.E., Faraone, S.V., Grevet, E.H., et al. (2019). The Role of Gene Encoding Variation of DRD4 in the Relationship between Inattention and Seasonal Daylight, Preprint.


Kong, X.Z., Mathias, S.R., Guadalupe, T., ENIGMA Laterality Working Group, Glahn, D.C., Franke, B., Crivello, F., Tzourio-Mazoyer, N., Fisher, S.E., Thompson, P.M., Francks, C. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium, PNAS 115, E5154-E5163.

Noz, M.P., Ter Telgte, A., Wiegertjes, K., Joosten, L.A.B., Netea, M.G., de Leeuw, F.E., Riksen, N.P. (2018). Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease, Stroke 49, 2910-2917.

Smeland, O.B., Wang, Y., Frei, O., Li, W., Hibar, D.P., Franke, B., Bettella, F., Witoelar, A., Djurovic, S., Chen, C.H., Thompson, P.M., Dale, A.M., Andreassen, O.A. (2018). Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms, Schizophrenia Bulletin 44, 854–864.

van der Meer, D., Rokicki, J., Kaufmann, T., Córdova-Palomera, A., Moberget, T., Alnæs D., et al. (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes, Molecular Psychiatry Epub.

van Donkelaar, M.M.J., Hoogman, M., Pappa, I., Tiemeier, H., Buitelaar, J.K., Franke, B., Bralten, J. (2018). Pleiotropic Contribution of MECOM and AVPR1A to Aggression and Subcortical Brain Volumes, Frontiers in Behavioral Neuroscience 61, Epub.

van Pelt, S., Shumskaya, E., Fries, P. (2018). Cortical volume and sex influence visual gamma, NeuroImage 178, 702-712.

Vrijsen, J.N., Tendolkar, I., Onnink, M., Hoogman, M., Schene, A.H., Fernández, G., van Oostrom, I., Franke B. (2018). ADHD symptoms in healthy adults are associated with stressful life events and negative memory bias, Attention Deficit Hyperactivity Disorders 10, 151-160.


Gialluisi, A., Guadalupe, T., Francks, C., Fisher, S.E. (2017). Neuroimaging genetic analyses of novel candidate genes associated with reading and language, Brain and Language 172, 9-15.

Guadalupe, T., Mathias, S.R., van Erp, T.G.M., Whelan, C.D., Zwiers, M.P., Abe, Y., et al. (2017). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex, Brain Imaging and Behavior 11, 1497-1514.

Hibar, D.P., Adams, H.H.H., Jahanshad, N., Chauhan, G., Stein, J.L., Hofer, E., et al. (2017). Novel genetic loci associated with hippocampal volume, Nature Communications 8, Epub.

Kavaklioglu, T., Guadalupe, T., Zwiers, M., Marquand, A.F., Onnink, M., Shumskaya, E., Brunner, H., Fernandez, G., Fisher, S.E., Francks, C. (2017). Structural asymmetries of the human cerebellum in relation to cerebral cortical asymmetries and handedness, Brain Structure and Function 222, 1611-1623.

Uddén, J., Snijders, T.M., Fisher, S.E., Hagoort, P. (2017). A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus, Brain and Language 172, 16-21.

van der Auwera, S., Wittfeld, K., Shumskaya, E., Bralten, J., Zwiers, M.P., Onnink, A.M., Usberti, N., Hertel, J., Völzke, H., Völker, U., Hosten, N., Franke, B., Grabe, H.J. (2017). Predicting brain structure in population-based samples with biologically informed genetic scores for schizophrenia, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174, 324-332.


Adams, H.H., Hibar, D.P., Chouraki, V., Stein, J.L., Nyquist, P.A., Rentería, M.E., et al. (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association, Nature Neuroscience 19, 1569-1582.

Becker, M., Guadalupe, T., Franke, B., Hibar, D.P., Renteria, M.E., Stein, J.L., Thompson, P.M., Francks, C., Vernes, S.C., Fisher, S.E. (2016). Early developmental gene enhancers affect subcortical volumes in the adult human brain, Human Brain Mapping 37, 1788-1800.

Everaerd, D., Klumpers, F., Zwiers, M., Guadalupe, T., Franke, B., van Oostrom, I., Schene, A., Fernández, G., Tendolkar, I. (2016). Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology, Neuropsychopharmacology 41, 1716-1723.

Woo, Y.J., Wang, T., Guadalupe, G., Nebel, R.A., Vino, A., Del Bene, V.A., Molholm, S., Ross, L.A., Zwiers, M.P., Fisher, S.E., Foxe, J.J., Abrahams, B.S. (2016). A Common CYFIP1 Variant at the 15q11.2 Disease Locus Is Associated with Structural Variation at the Language-Related Left Supramarginal Gyrus, PLoS One 11, Epub.


Brucato, N., Guadalupe, T., Franke, B., Fisher, S.E., Francks, C. (2015). A schizophrenia-associated HLA locus affects thalamus volume and asymmetry, Brain, Behavior, and Immunity 46, 311-318.

Chen, J., Calhoun, V.D., Arias-Vasquez, A., Zwiers, M.P., van Hulzen, K., Fernández, G., Fisher, S.E., Franke, B., Turner, J.A., Liu, J. (2015). G-protein genomic association with normal variation in gray matter density, Human Brain Mapping 36, 4272-4286.

Guadalupe, T., Zwiers, M.P., Wittfeld, K., Teumer, A., Vasquez, A.A., Hoogman, M., Hagoort, P., Fernandez, G., Buitelaar, J., van Bokhoven, H., Hegenscheid, K., Völzke, H., Franke, B., Fisher, S.E., Grabe, H.J., Francks, C. (2015). Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activityCortex 62, 41-55.

Hibar, D.P, Stein, J.L, Renteria, M.E., Arias-Vasquez A., Desrivières, S., Jahanshad, N., et al. (2015). Common genetic variants influence human subcortical brain structures, Nature 520, 224-229.

Vrijsen, J.N., Tendolkar, I., Arias-Vasquez, A., Franke, B., Schene, A.H., Fernández, G., van Oostrom, I. (2015). Interaction of the 5-HTTLPR and childhood trauma influences memory bias in healthy individuals, Journal of Affective Disorders 186, 83-89.


Cai, D.C., Fonteijn, H., Guadalupe, T., Zwiers, M., Wittfeld, K., Teumer, A., Hoogman, M., Arias-Vásquez, A., Yang, Y., Buitelaar, J., Fernández, G., Brunner, H.G., van Bokhoven, H., Franke, B., Hegenscheid, K., Homuth, G., Fisher, S.E., Grabe, H.J., Francks, C., Hagoort, P. (2014). A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl'sgyrusGenes, Brain, and Behavior 13, 675-685.

Chen, J., Liu, J., Calhoun, V.D., Arias-Vasquez, A., Zwiers, M.P., Gupta, C.N., Franke, B., Turner, J.A. (2014). Exploration of scanning effects in multi-site structural MRI studies, Journal of Neuroscience Methods 230, 37-50.

Cousijn, H., Eissing, M., Fernández, G., Fisher, S.E., Franke, B., Zwiers, M., Harrison, P.J., Arias-Vásquez, A. (2014). No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structureSchizophrenia research 159, 329-332.

Guadalupe, T., Willems, R.M., Zwiers, M.P., Arias Vasquez, A., Hoogman, M., Hagoort, P., Fernandez, G., Buitelaar, J., Franke, B., Fisher, S.E., Francks, C. (2014). Differences in cerebral cortical anatomy of left- and right-handersFrontiers in Psychology, Epub.

Guadalupe, T., Zwiers, M.P., Teumer, A., Wittfeld, K., Vasquez, A.A., Hoogman, M., Hagoort, P., Fernandez, G., Buitelaar, J., Hegenscheid, K., Völzke, H., Franke, B., Fisher, S.E., Grabe, H.J., Francks, C. (2013). Measurement and genetics of human subcortical and hippocampal asymmetries in large datasetsHuman Brain Mapping 35, 3277-3289.

Hoogman, M., Guadalupe, T., Zwiers, M.P., Klarenbeek, P., Francks, C., Fisher, S.E. (2014). Assessing the effects of common variation in the FOXP2 gene on human brain structureFrontiers in Human Neuroscience, Epub.

Mennes, M., Jenkinson, M., Valabregue, R., Buitelaar, J.K., Beckmann, C., Smith, S. (2014). Optimizing full-brain coverage in human brain MRI through population distributions of brain size, Neuroimage 98, 513-530.

Vogel, S., Gerritsen, L., van Oostrom, I., Arias-Vásquez, A., Rijpkema, M., Joëls, M., Franke, B., Tendolkar, I., Fernández, G. (2014). Linking genetic variants of the mineralocorticoid receptor and negative memory bias: interaction with prior life adversityPsychoneuroendocrinology 40, 181-190.


Chavarría-Siles I., Rijpkema M., Lips E., Arias-Vásquez A., Verhage M., Franke B., Fernández G., and Posthuma D. (2013). Genes Encoding Heterotrimeric G-proteins Are Associated with Gray Matter Volume Variations in the Medial Frontal CortexCerebal cortex 23, 1025-1030.

den Ouden, H.E., Daw, N.D., Fernandez, G., Elshout, J.A., Rijpkema, M., Hoogman, M., Franke, B., Cools R. (2013). Dissociable effects of dopamine and serotonin on reversal learningNeuron 80, 1090-1100.

van der Heijden, C.D., Rijpkema, M., Arias-Vásquez, A., Hakobjan, M., Scheffer, H., Fernández, G., Franke, B., van de Warrenburg, B.P. (2013). Genetic Variation in Ataxia Gene ATXN7 Influences Cerebellar Grey Matter Volume in Healthy AdultsCerebellum 12, 390-395.


Cousijn, H., Rijpkema, M., Harteveld, A., Harrison, P.J., Fernández, G., Franke, B., and Arias-Vásquez, A. (2012). Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure: an MRI study in 892 volunteersMolecular Psychiatry 17, 1155-1157.

Everaerd, D., Gerritsen, L., Rijpkema, M., Frodl, T., van Oostrom, I., Franke, B., Fernández, G., Tendolkar, I. (2012). Sex Modulates the Interactive Effect of the Serotonin Transporter Gene Polymorphism and Childhood Adversity on Hippocampal VolumeNeuropsychopharmacology 37, 1848-1855.

Gerritsen, L., Rijpkema, M., van Oostrom, I., Buitelaar, J., Franke, B., Fernández, G., and Tendolkar, I. (2012). Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjectsPsychological Medicine 42, 335-343.

Gerritsen, L., Tendolkar, I., Franke, B., Vasquez, A.A., Kooijman, S., Buitelaar, J., Fernández, G., and Rijpkema, M. (2012). BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjectsMolecular Psychiatry 17, 597-603.

Hoogman, M., Rijpkema, M., Janss, L., Brunner, H., Fernandez, G., Buitelaar, J., Franke, B., and Arias-Vásquez, A. (2012). Current self-reported symptoms of attention deficit/hyperactivity disorder are associated with total brain volume in healthy adultsPLoS One 7, Epub.

Luo, X., Li, M., Huang, L., Nho, K., Deng, M., Chen, Q., Weinberger, D.R., Arias-Vásquez, A., Rijpkema, M., Mattey, V.S., Saykin, A.J., Shen, L., Fernández, G., Franke, B., Chen, J., Chen, X., Wang, J., Xiao, X., Qi, X., Xiang, K., Peng, Y., Cao, X., Li, Y., Shi, X., Gan, L., Su, B. (2012). The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural ProgenitorsPloS One 7, Epub.

Rijpkema, M., Everaerd, D., van der Pol, C., Franke, B., Tendolkar, I., and Fernández, G. (2012). Normal sexual dimorphism in the human basal gangliaHuman Brain Mapping 33, 1246-1252.

Smolders, R., Rijpkema, M., Franke, B., and Fernández, G. (2012). BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humansBrain and behavior 2, 726-731.

Stein, J.L., Medland, S.E., Vasquez, A.A., Hibar, D.P., Senstad, R.E., Winkler, A.M., et al. (2012). Identification of common variants associated with human hippocampal and intracranial volumes, Nature Genetics 44, 552-561.

van Oostrom, I., Franke, B., Rijpkema, M., Gerritsen, L., Arias-Vásquez, A., Fernández, G., and Tendolkar, I. (2012). Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women, Biological Psycholology 89, 214-219.


Bralten, J., Arias-Vásquez, A., Makkinje, R., Veltman, J.A., Brunner, H.G., Fernández, G., Rijpkema, M., and Franke, B. (2011). Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adultsAmerican Journal of Psychiatry 168, 1083-1089.

Bralten, J., Franke, B., Arias-Vásquez, A., Heister, A., Brunner, H.G., Fernández, G., and Rijpkema, M. (2011). CR1 genotype is associated with entorhinal cortex volume in young healthy adultsNeurobiology of Aging 32, 2107-2111.


Franke, B., Vasquez, A.A., Veltman, J.A., Brunner, H.G., Rijpkema, M., and Fernández, G. (2010). Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individualsBiological Psychiatry 68, 586-588.