Thesis defense Ashutosh Mishra (Donders series 486)

17 February 2021

Promotors: Prof. dr. Paul H.E. Tiesinga, Prof. dr. Tansu Celikel
Co-promotors: Dr. Bernhard Englitz, Dr. Michael X Cohen

Multiscale Microstates (Uniform spatiotemporal analysis across spatial scales

EEG microstates, the short quasi stable spatial patterns of scalp recordings, have become a widely used spatiotemporal analysis method to study cognition. However, key assumptions of EEG microstate transitions remain untested. Moreover, irrespective of numerous studies on “neural states” at Macroscale (EEG/MEG/fMRI) and Mesoscale (LFP/MUA), there seems to be a lack of uniform approach towards methodological definition of neural states across multiple scales. The first part of this thesis investigates the key assumptions of EEG microstates using a geometrical approach. In the second half, EEG microstate approach has been translated on multisensor LFP recordings from three brain regions (PFC, STR and VTA) and their physiological and behavioral significance have been discussed.