Many patients suffer from chest pain, also without obstructed coronary arteries. Coronary vasomotor dysfunction might be the underlying disease: an abnormal functioning of the coronary arteries, causing a spasm or high vascular resistance. This was previously hard to diagnose, through which many patients remained undiagnosed. This thesis shows that coronary vasomotor dysfunction is prevalent in up to 86% of patients with chest pain in the absence of obstructed coronary arteries. The researchers show that the diagnosis can be made by a coronary function test, an invasive test of the coronary vasomotor function, also diagnosing the specific type of dysfunction. And this influences treatment options. They also research a novel method to measure coronary flow, that shows promising. These novel insights improve the diagnosis and treatment of patients with coronary vasomotor dysfunction.
Regina Konst (1992) graduated from medical school in 2015, at the University of Groningen, and initiated her career as cardiology resident at the Radboudumc Nijmegen. She started her PhD at the same department in 2017, resulting in the current thesis. In 2021 she commenced her cardiology specialty training as a resident, currently working in the Rijnstate hospital, Arnhem.