One in 3 people will get cancer. The immune system plays an important role in the clearance and control of cancer cells. One of the important players is the T cell, they can recognize and kill cancer cells when they are properly activated. Recently biomaterials have been developed to properly activate and steer the T cells. The work done in this thesis has provided new insights into the parameters which are important for the development of biomaterials. We have investigated both 2D and 3D systems and looking into the effect of signal presentation on the T cells. These results help with the development of new biomaterial designs that have more control and are more efficient in T cell activation. These results bring the improvement of cancer immunotherapy closer.
Marjolein Schluck (1994) obtained her bachelor’s degree Biomedical Sciences, cum laude, at Maastricht University. In 2018 she obtained her Master’s degree Biomedical sciences, cum laude, at the Radboud University Nijmegen. After which she started in 2018 with her PhD as part of the tumor immunology department at the Radboudumc. Currently, she is working as a Postdoc at the same department.