Bone healing in diabetic and osteoporotic conditions: Effects of systemic therapy and material optimizations on healing.

Thursday 16 March 2023, 10:30 am
Promovendus
W.A. Camargo
Promotor(s)
prof. dr. J.A. Jansen, dr. ing. J.J.J.P. van den Beucken
Co-promotor(s)
dr. J.W.M. Hoekstra
Location
Aula

Worldwide, the number of older people is expected to increase significantly in the upcoming decades. According to UN, one in six people is supposed to be above 65 years by 2050. Subsequently, the number of diabetic and osteoporotic people is expected to increase drastically due to ageing. Diabetes and osteoporosis are characterised by delayed and/or impaired bone regeneration, and surgical procedures involving bone replacement or augmentation may negatively affect clinical outcomes and increase the number of clinical failures. This research proved the reduced bone formation for diabetic and osteoporotic conditions when a bone substitute is used in animal models. We also mimic a human situation, where osteoporotic medication was given to animals and confirmed the beneficial effect of the drug, leveraging bone formation to levels compared to normal. Finally, within this research, we participate in the development of bone substitutes and implant surfaces capable of enhancing bone formation.

Winston Adam Camargo(1980) obtained his dental degree at the State University of Ponta Grossa(Brazil) in 2006, after he successfully completed the Specialization in Periodontology, and a Masters in Dental Medicine at University of Porto(Portugal). In 2014, he started with his PhD research in the Department of Dentistry(Biomaterials), at the RadboudUMC. Currently, he is working as periodontist and teaching at the Trinity College(Ireland).