Turner syndrome occurs in approximately 1 in 2,500 girls and is often accompanied by an accelerated decline in oocytes, which reduces fertility. Many girls have already lost their oocytes before they develop a desire to have children. If fertility preservation is considered, such as freezing oocytes or ovarian tissue, this must occur before the oocyte reserve is depleted. However, it is difficult to predict exactly when that moment will arrive. This thesis shows that repeated measurements of the hormone AMH, in combination with the girl's development, can help determine the right moment. In addition, it appears that oocytes from frozen ovarian tissue can continue to develop after transplantation, although there are concerns about their quantity and quality. Discussing parenting options affects the well-being of girls with Turner syndrome, but with good guidance and information, they can consciously think about this at a young age.
Sanne van der Coelen (1994) obtained her master's degree in medicine at Radboud University in 2019 after which she worked as a fertility doctor. In 2020, she started her PhD at the Department of Obstetrics and Gynecology at Radboudumc. She is currently working as a doctor in gynecology at Rijnstate Hospital. In May, she will start the training as gynecologist within cluster Nijmegen.