Harnessing trained immunity: unlocking the power of vaccines for enhanced protection.

Tuesday 30 April 2024, 10:30 am
PhD student
A. Debisarun
Promotor(s)
prof. dr. M.G. Netea, prof. dr. R. van Crevel
Co-promotor(s)
dr. J. Dominguez Andres
Location
Aula

The thesis explores the leveraging of existing vaccines to provide protection against diverse pathogens beyond their original target through a phenomenon known as Trained Immunity (TRIM). TRIM can last 1 to 2 years and is driven by epigenetic and metabolic changes in innate cells. Vaccines like BCG, MMR, and influenza were examined for their ability to induce TRIM. Different aspects such as dosing, seasonality and immune pathways were investigated, using advanced omics technologies. The vaccines showed distinct trained immunity profiles, varying in pro-inflammatory or anti-inflammatory tendencies based on both vaccine type and encountered pathogens. Moreover, vaccines exhibit systemic effects, with gender-specific patterns. As vaccination strategies evolve, encompassing annual influenza and COVID-19 vaccinations, understanding the full immunological landscape of vaccines including their potential in inducing trained immunity and interactions with other vaccines will be crucial for shaping future immunization strategies.

Priya A. Debisarun (born 1991, Waalwijk) obtained her Bachelor's degree in Biology in 2012. In 2017, she obtained her medical degree. She worked as a medical resident in Internal Medicine for 2 years and began her PhD trajectory in 2019 at the Department of Experimental Internal Medicine, focusing on trained immunity.