Aki Minoda
Aki Minoda

Huygens Colloquium: Aki Minoda

Monday 3 June 2024, 12:30 pm - 1:15 pm
Ageing: The Next Frontier

Ageing is a major risk factor for many diseases including infections, autoimmune diseases, type 2 diabetes, osteoarthritis, cancers, and atherosclerosis. Many societies in the world are facing increasingly larger proportion of individuals over 65 years old compared to the working population. Extending healthy longevity, in other words how long you can stay healthy and active disease-free, is considered to be our next frontier. The question we ask in our lab is, what aspects of ageing make us more susceptible to developing various diseases? We are tackling this question by studying how tissues age at the cellular level (“cellular ageing”).

There are many hallmarks of ageing, one of which is chronic low-grade inflammation, for which there is a coined term called inflammageing. Infections by micro-organisms such as viruses and bacteria certainly induce acute inflammation as part of our defence system. But what about the microbiota (collection of micro-organisms) we live with, that are in and on our body? Do they play a role in causing inflammageing? This is one question we decided to look into by comparing how various tissues age in mice with microbiota as to the mice that don’t have any microbiota (and kept in a sterile environment) called germ-free mice. 

In this talk, I will share the progress of our analysis on the Mukin Mouse Ageing Atlas (Mukin means germ-free in Japanese) that we have constructed using single cell RNA-seq technology.

Huygens Colloquia

In the Faculty of Science a great diversity of exciting research is going on. After some years of silence – due to the Covid-lockdowns – the Huygens Colloquia are back to present research highlights to a wider audience. 

The Huygens Colloquia are a colloquium series by Faculty of Science employees for all faculty employees and students. Every month, a colleague will discuss their science and their latest results in an accessible way. Access is free and no registration is needed. Bring your own lunch, coffee, and tea will be provided.

When
Monday 3 June 2024, 12:30 pm - 1:15 pm
Speaker
Aki Minoda
Contact information

For more information, please get in touch with Henk de Regt.