Jorge V. José
Physics Department, Bloomington, Indiana
Stark Neuroscience Research Institute,
Adjunct Professor of Cellular & Integrative Physiology,
Indiana University School of Medicine, Indianapolis
Indiana University, USA
Movement is an essential part of the sequential dance of behaviors that comprise fluid social communications. The simple act of reaching an object — an act accomplished easily many times per day—demands an incredible amount of coordination between the visual field to locate the object to initiate the reach movement toward the object. Daily movements considered separately or in an aggregate, can reveal a great deal about neuromotor control and cognitive abilities. It has been recognized that atypical movements may interfere with the development of adaptive skills, for children with neurodevelopmental disorders (NDD). We measured several kinematic variables using millisecond motor sensors, away from naked eye detection, when NDD individuals performed a reaching paradigm. Studying new participants, first doing a Deep Learning analyses of trained electronic noisy signal we can diagnose new NDD conditions with close to 90% accuracy. Next, after filtering the electronic noise, we introduced new statistical biomarkers and biometrics that quantify the degree of severity of each NDD participant. In this lecture I will discuss the relationship between the DNA of how a person moves with their cognitive abilities [1-3].
[1] E. B. Torres, J. V. José et al., Autism: the micro-movement perspective. Frontiers in integrative neuroscience 7, 32 (2013).
[2] D. Wu, J. V. José, J. I. Nurnberger, and E. B. Torres, “A biomarker characterizing neurodevelopment with applications in autism”. Scientific Reports (Nature) 8, 1–14 (2018).
[3] K. P. Doctor, J. V. José et al. “AI Screening plus Statistical Severity Biometric Studies of Neurodivergent Disorders” (under review at PNAS Nexus).