Operative techniques and postoperative anastomotic leakage in patients with esophageal cancer

Friday 20 January 2023, 10:30 am
M. Verstegen MSc.
Prof. dr. C. Rosman, Prof. dr. M. M. Rover

An esophagectomy (i.e. the surgical removal of the esophagus) is a complex operation and can be performed using various techniques. Anastomotic leakage, leakage of the new connection (anastomosis) between the remnant esophagus and surgically altered stomach, is a severe complication after this procedure.

The first part of this thesis shows that an anastomosis in the chest is associated with a lower incidence of anastomotic leakage and other severe complications, a shorter hospital length of stay and a better quality of life as compared to an anastomosis in the neck.

In the second part of this thesis, data is presented showing that the sequelae of an anastomotic leakage in the neck is generally less severe than an anastomotic leakage in the chest. This thesis also shows that there is no robust evidence for a uniform treatment strategy for anastomotic leakage and investigates how this can be handled in the future.

Moniek Verstegen (1992) obtained her Master’s degree in Medicine at the Radboud University in 2017 and started working as a PhD student at the Radboudumc in Nijmegen. At the same time, she worked as a surgical resident not in training at the Radboudumc and Imperial College London NHS Trust. Currently, she works as a surgical trainee at the Slingeland Ziekenhuis in Doetinchem.