Children frequently need drug treatment. However, many drugs given to children have never been properly studied. Even though the pharmacokinetics, movement of drug into, through, and out of the body, can be different in children of all ages. This can lead to differences in drug exposure and therewith treatment failure or a harmful overdose.This thesis shows that drug therapy in children is rarely based on high-quality research and often relies only on doctors' experiences, especially in the youngest children. In addition, the results demonstrate how renal function changes with age and how renal function can best be determined in critically ill children. In this way, dosing regimens can be better tailored to kidney function and kidney failure can be better diagnosed. By recognising age-specific differences in kidney function between adults and children, drug therapy in children can be better substantiated.
Nori Smeets (1992) obtained her medical degree at the Radboud University in 2018, after which she started with her PhD research at the Department of Pharmacology and Toxicology. She was trained as a clinical pharmacologist and worked as a resident at the paediatric intensive care unit. Currently, she is working as a paediatric resident in training at the Canisius Wilhelmina Hospital.