Playing with materials to provide a degradable, injectable calcium phosphate cement

Wednesday 3 July 2024, 10:30 am
PhD candidate
E.-C. Grosfeld drs.
Promotor(s)
prof. dr. J.A. Jansen, dr. ing. J.J.J.P. van den Beucken
Co-promotor(s)
dr. J.W.M. Hoekstra
Location
Aula

When a bone fracture is unable to heal because of extensive bone loss, bone grafts are used. Synthetic bone grafts such as injectable calcium phosphate cement (CPC) are an interesting alternative for donor bone from the patient since these do not involve an extra surgical site and are unlimitedly available. CPC should be replaced by newly formed bone to regain function and stability. Degradation of CPC takes place when the surface of the CPC is able to interact with bodily fluids and cells can penetrate the cement. Unfortunately, the pores in CPC are too small for cell penetration. Creating an interconnective network of macropores by adding fast degrading or dissolving materials to CPC is essential. This thesis showed the great potential of a novel approach that leverages simple material properties to generate completely degradable, injectable CPCs with distinct bone regeneration profiles.

Eline-Claire Grosfeld (1987) completed her Master in Medicine (MSc) at Maastricht University in 2012 after which she worked as a medical doctor at the department of Surgery. In 2014 she started her PhD research at the Department of Biomaterials of Radboudumc. Currently, she is working as a medical doctor in Cosmetic Medicine.