The use of morphine gel on painful wounds.

Tuesday 25 June 2024, 12:30 pm
PhD candidate
M.M.P.M. Jansen
prof. dr. D.M. Burger, prof. dr. Y.A. Hekster †

The treatment of wound pain with oral painkillers, regularly provides insufficient pain relief and is often accompanied by unpleasant side effects. Morphine administered by tablet or injection has its site of action in the central nervous system and the entire body is exposed to the drug. Locally applying morphine in the form of a hydrogel to a painful wound is believed to have a direct effect on receptors on the endings of nociceptive nerves in the skin. Due to the small amount and local effect of morphine, the risk of side effects is very small. Unfortunately, morphine gel does not work on all painful wounds. This thesis investigated which types of painful wounds are likely to experience an analgesic effect from morphine gel. An explanation for the difference in effect was also sought. In addition, research has been conducted into how to prepare, package and store morphine hydrogel in a pharmaceutically safe and responsible manner and at what speed the morphine is released from the hydrogel into the wound surface. The latter is important for how long the analgesic effect lasts after applying the hydrogel to the wound.

Mark Jansen (1975) obtained his PharmD from Utrecht University in 1999 after which he followed a hospital pharmacy residence training in Rijnstate hospital in Arnhem and specialization as clinical pharmacologist at the Radboud University Medical Centre. Since 2005 he works as a hospital pharmacist and clinical pharmacologist at Elisabeth-TweeSteden hospital in Tilburg. Almost at the same time he started his research on topical use of morphine hydrogel in painful wounds, alongside his clinical duties.