Designing synthetic models
ComeInCell focuses on creating sustainable, efficient models to replicate cellular processes, allowing researchers to unravel the mechanisms of cellular functions, training the next generation of scientists in synthetic biology. They will explore how cells grow, change, and sometimes malfunction, which could lead to diseases such as cancer. ComeInCell unites leading experts in biophysics, nanotechnology, and bioengineering from thirteen universities and research institutes in nine countries. “This consortium will enable us to bring the best of two chemical worlds together with world-leading experts in both biomolecular condensates and membranes. We look forward to building the next generation of synthetic cells with significant impact not only on fundamental science but also on medical applications”, Spruijt says.
PhD programme to advance cell research
The network will recruit 17 PhD candidates from across Europe, including one candidate who will join IMM. PhD candidates in ComeInCell will attend annual retreats and gain hands-on experience in 2 to 3 labs, connecting with peers and mentors. They will participate in workshops and lectures focused on skills for synthetic cell development, emphasizing sustainability and cost-effectiveness. This program combines academia and industry to provide valuable skills. PhD’s will also work at partner companies in biotechnology and software development, and they will have opportunities to collaborate with editorial teams of two leading scientific journals. With the launch of ComeInCell, students can explore and push the boundaries of cell research.
Soft Interfaces
Evan Spruijt is head of the Soft Interfaces group, which is part of the Physical Organic Chemistry department. The research group is part of the IMM. The group aims to create artificial organelles that can be used as functional compartments in synthetic cells or as model systems to elucidate the role of coacervates in cells and in the origin of life. The group studies if natural selection and molecular evolution between different coacervate species could result from the natural tendency of coacervates to take up other molecules.
