Experimental Psychopathology and Treatment

Research group

At EPT, we aim to acquire fundamental scientific and applied knowledge to better understand the cognitive, behavioural, and neurobiological mechanisms of psychopathology and its treatment. We strive to achieve this goal through the empirical study of clinically relevant processes such as biased information and affective processing, approach-avoidance tendencies, cognitive control, emotion regulation, motivation, and executive functioning. 

Research projects

Paul and Gero in action


We developed a free virtual reality smartphone app, allowing elementary school children to practice presentations in front of virtual audiences. The app helps to increase presentation skills and can potentially prevent fear of public speaking.

Decision Under Stress Training (DUST)

In this project, we train police officers to control their stress physiology in engagingly provoking situations with a Virtual Reality biofeedback game

Whether biased attention, interpretation and memory process are interacted

This project aims to better understand the underlying mechanisms of emotional and independence disorders and help develop multiple treatments targeting combined cognitive biases to intervene in the related symptoms.


We study these processes in healthy and various sub-clinical and clinical populations, including people with anxiety, depression, eating disorders and addiction. This assesses their role in 1) the development and maintenance of psychological disorders, 2) change promoted by clinical and preventive interventions, 3) decision-making by patients and clinicians, and 4) improvement of treatment selection and maximisation of treatment efficacy. 

Investigating Clinically Relevant Processes

The Experimental Psychopathology and Treatment (EPT) programme stands out for its comprehensive and meticulous examination of clinically relevant processes. 

Research methods

We firmly believe that a multi-modal approach to studying these processes and their modification is key to gaining a deeper understanding of psychopathology and fostering innovation in treatment and prevention. Our research methods encompass a broad spectrum, including measuring reaction times and verbal reports, behavioural assessments conducted in real and virtual environments, eye-tracking studies, physiological response analysis, neuroimaging and neuromodulation techniques and applying computational modelling. The fusion of fundamental research with practical clinical applications is one of the distinctive strengths of the EPT programme.

Collaborative Endeavors and Real-World Impact

Our research thrives on intensive collaborations within the BSI and Radboud University, as well as health care institutes, clinics and social partners within the Netherlands and internationally. These partnerships provide a robust foundation for translating fundamental research findings into meaningful clinical and social applications.

Contact information


Maria Montessori building

Thomas Van Aquinostraat 4
6525GD Nijmegen
Postal address
Postbus 9104