Motivational & Cognitive Control

Research group

Our overarching goal is to understand the neural and neurochemical mechanisms underlying flexible and adaptive behavior and decision making. Such adaptive behaviour requires motivational and cognitive control as well as reinforcement learning.

I aim to characterize: (i) the distinct contribution of subcortical structures, such as the basal ganglia, from that of the prefrontal cortex; (ii) the role of neuromodulators, in particular dopamine and serotonin and (iii) individual differences at the level of personality traits, baseline neurotransmitter levels, structural connectivity and genotypic variation.

To this end, I combine cognitive psychology with psychopharmacology, functional neuroimaging, structural neuroimaging, neurochemical (PET) imaging, computational modeling, and patient studies (e.g. Parkinson’s disease & ADHD).

Projects

  • CHEMCONTROL (ERC Advanced grant, entitled ‘Balancing brain chemicals for boosting meta-control’) to unravel the distinct roles of dopamine and serotonin in the adaptive tuning of different, often opponent behavioral control strategies to our constantly changing environment. In the project we study behavioral, neurochemical, BOLD and physiological stress responses as a function of statistical meta-decision parameters like environmental controllability, volatility and richness. To this end we combine psychophysiology, pharmacology, fMRI, ultrasound neuromdulation, computational modeling and chemical PET imaging. 
     
  • LAMINARGATE (NWO grant, entitled ‘Unraveling dopamine’s role as gatekeeper of prefrontal cortex’) to adjudicate between different pervasive dopamine models of working memory-gating. To this end  we integrate psychopharmacology with ultrahigh-resolution fMRI (at 7T in Essen) for measuring neural activity in cortical layers. Hypotheses are grounded in knowledge about the anatomy of feedforward and feedback flow of information between different cortical layers and about layer-specificity of dopamine receptor distributions.
     
  • CONTROLPD (funded by a JPND grant with Rick Helmich, entitled: ‘COgNiTive propagation in pRodrOmaL Parkinson’s disease’) to unravel the cognitive nature of clinical heterogeneity in PD. In this context, we have set up an online task battery for assessing working memory, reinforcement learning, paired associative learning and behavioral control estimation in a large sample of patients, from all over the world.  

Key grants and prizes
 

SCIENTIFIC AWARDS AND PERSONAL FELLOWSHIPS

  • 2022                     ERC Advanced Grant
  • 2021                     Lead Scientist Voucher from Human Brain Project
  • 2017                     Ammodo Science Award in Social Sciences (KNAW)
  • 2015                     Vici award from the Netherlands Organization for Scientific Research
  • 2012                     James McDonnell Scholar Award
  • 2012                     Young Investigator Award of the Cognitive Neuroscience Society
  • 2011                     Radboud Science Award for best research at Radboud University
  • 2008                     Vidi award from the Netherlands Organization for Scientific Research
  • 2006                     Royal Society University Research Fellowship, University of Cambridge UK
  • 2002                     Royal Society Dorothy Hodgkin Research Fellowship, University of Cambridge UK


HONOURS AND RECOGNITIONS

  • 2023                     Elected Member of the Koninklijke Hollandsche Maatschappij der Wetenschappen (KHMW)
  • 2022                     Elected Member of the Netherlands Academy of Technology and Innovation (AcTI)
  • 2018                    Elected Member of the Royal Netherlands Academy of Arts and Sciences (KNAW)
  • 2018                     Elected Member of the International Neuropsychological Society (INS)
  • 2018                     Elected Member of the Academia Europaea

Key publications

  • Tichelaar JG, Hezemans F, Bloem BR, Helmich RC*, Cools R* (2024). Neural reinforcement learning signals predict recovery from impulse control disorder symptoms in Parkinson’s disease. Biological Psychiatry: S0006-3223(24)01434-3.
  • Sayali C, van den Bosch R, Määttä J, Hofmans L, Papadopetraki D, Booij J, Verkes R-J, Baas M, Cools R (2023). Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity. Neuropsychopharmacology.
  • Sayali C, Heling E, Cools R (2023). Learning progress mediates the link between cognitive effort and task engagement. Cognition 236: 105418
  • Romero Verdugo P, van Lieshout LLF, de Lange FP, Cools R (2023). Choice Boosts Curiosity. Psychol Sci. 34(1):99-110
  • van den Bosch R, Lambregts B, Määttä J, Hofmans L, Papadopetraki D, Westbrook A, Verkes RJ, Booij J, Cools R (2022). Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning. Nature Communications 24;13(1):4962
  • Geurts DEM, Van den Heuvel TJ, Huys QJM, Verkes RJ, Cools R (2022). Amygdala response predicts clinical symptom reduction in patients with borderline personality disorder: a pilot fMRI study. Frontiers in Behavioral Neuroscience, section Learning and Memory.
  • Ligneul R, Mainen Z, Cools R (2022). Stress-sensitive inference of task controllability. Nat Hum Behav 2022 Jun;6(6):812-822.
  • Cools R and Arnsten A (2021). Neuromodulation of prefrontal cortex cognitive function in primates: The powerful roles of monoamines and acetylcholine. Neuropsychopharmacology 47(1):309-328.
  • Westbrook A, Frank MJ, Cools R (2021) A mosaic of cost-benefit control over cortico-striatal circuitry. Trends in Cognitive Sciences 25(8):710-721
  • Westbrook A*, Ghosh A*, van den Bosch R, Määttä JI, Hofmans L, Cools R (2021) Striatal dopamine synthesis capacity reflects smartphone social activity. iScience 24(5):102497
  • Westbrook A, van den Bosch R, Määttä JI, Hofmans L, Papadopetraki D, Cools R* & Frank MJ* (2020). Dopamine Promotes Cognitive Effort by Biasing the Benefits Versus Costs of Cognitive Work. Science 367 (6484): 1362-1366 
  • Brolsma S, Vrijsen J, Vassena, Kandroodi MR, Bergman A,van Eijndhoven P, Collard R, den Ouden HEM, Schene A*, Cools R* (2020). Challenging the negative learning bias hypothesis of depression: Reversal learning in a naturalistic psychiatric sample. Psychological Medicine 52(2):303-313. doi:10.1017/S0033291720001956
  • Cools R (2019). Chemistry of the Adaptive Mind: Lessons from Dopamine. Neuron. 104(1):113-131
  • Cook JL, Swart JC, Froböse MI, Diaconescu AO, Geurts DEM, den Ouden HEM* & Cools R* (2019). Catecholaminergic modulation of meta-learning. Elife 8:e51439.
  • Cools R (2016). The costs and benefits of brain dopamine for cognitive control. Wiley Interdiscip Rev Cogn Sci 7(5):317-329

Links

Contact information

Location
024-3610651
Postal address
Postbus 9101
6500HB NIJMEGEN