Physical Organic Chemistry


The Physical Organic Chemistry research group (part of Institute for Molecules and Materials) is broadly interest in understanding the physical and (bio)chemical properties of complex molecular systems. 


Caroline Slomp & Wilhelm Huck summit grant

Summit Grants for research on climate change and the evolution of living cells

Wilhelm Huck and Caroline Slomp have both received a Summit Grant from the NWO with their research consortia.


NWO Summit Grant for studies on the evolution of living cells from lifeless molecules

A large consortium involving Wilhelm Huck, Professor in Physical Organic Chemistry at the Institute for Molecules and Materials (IMM) of Radboud University, has been awarded a NWO Summit Grant to work on the EVOLF programme.

Willem Velema

NWO Grant for research on novel antisense antibiotic therapeutics

Willem Velema, Assistant Professor in the Physical Organic Chemistry Group within the Institute for Molecules and Materials (IMM) of Radboud University, has been awarded an NWO grant within the NACTAR program.


The research conducted in the Physical Organic Chemistry group is divided into four different groups. 

Huck group

“Life. What is it? How does it work? Where could it possibly come from?” These are the key questions we aim to address, with the ultimate goal of constructing life from the bottom up. While we can usually recognise life, defining it precisely is challenging. Understanding how living systems work and how life can emerge from non-life are among the greatest scientific challenges of our time.

Read more about the Huck group


Spruijt group

We aim to create artificial organelles that can be used as functional compartments in synthetic cells or as model systems to elucidate the role of coacervates in cells and in the origin of life. We are currently investigating various (bio)chemical reactions to create, shape and grow these organelles in a dynamic way. In parallel, we use the compartments to direct reactions and regulate biological assembly processes.

Read more about the Spruijt lab

Korevaar group

Synthetic materials today are typically inactive and serve only one function. In contrast, living materials sense their environment, adapt to changes, and reorganise to perform multiple tasks. This behaviour is programmed at the molecular level. In our lab, we aim to integrate this life-like behaviour into synthetic materials so they can perform complex operations like motion, growth, or shape transformation in response to their environment, paving the way for a new generation of intelligent matter.

Read more about the Korevaar Life-Like Materials lab


Velema group

The goal of our laboratory is to harness chemistry to offer solutions for contemporary biomedical problems. We are particularly interested in nucleic acids and their role in antibacterial drug resistance. Our team consists of chemists, biologists and bioinformaticians that work together towards deciphering the molecular mechanisms involved in disease progression to ultimately help develop the next generation of antibacterials.

Read more about the Velema group

Mabesoone group

Nature evolved highly complex materials over billions of years of evolution. Designing biobased materials with similar properties is a challenging task. We combine high-throughput experimentation and machine learning for data-driven design and engineering soft materials.

Read more about the Mabesoone lab


Contact information


Huygens building

Heyendaalseweg 135
6525AJ Nijmegen
024-365 2676
Postal address
Postbus 9010