Radboud University
Research in the department for Human Biology is aimed towards understanding fundamental questions regarding the regulation of gene expression by chromatin architecture, the impact of cellular metabolism and the (micro)environment on the formation of chromatin states and transcriptional variability. The team is particularly interested in understanding these pathways during ageing and age-related diseases.
The department is part of Radboud Institute for Molecular Sciences.
The team of Peter Tessarz uses (primary) tissue cultures and 3D tissue models to dissect the connection between metabolism and epigenetics on a mechanistic level using biochemical, cell biological and deep-sequencing approaches, including spatial and single-cell resolution technologies.
A long-term goal of our research is to identify pathways within the metabolism-epigenetics axis that can be exploited for interventions to positively impact disease outcome and/or ageing.
I want to extend our research to a more clinical setting and investigate the link between the metabolism and the epigenome in human diseases.
