Research focus
The group, led by Richárd Bártfai, is exploring the biology of malaria parasites and their delicate interaction with the human host. We integrate (single-cell) multi-omic, bioinformatic, biochemical and genetic engineering approaches to identify key gene regulatory mechanisms that enable the parasite to develop and adapt to its host environment. These studies provide molecular insights into regulatory processes essential for the parasite survival and hence critical knowledge for the development of improved intervention strategies.
Epigenetic regulation of malaria parasite development and adaptation
- Histone marks and chromatin associated protein(complexe)s
- Molecular mechanisms regulating chromatin dynamics
- Transcriptional and epigenetic regulators of life cycle progression
- Novel methods to investigate chromatin biology
Host-parasite iteration regulating liver stage development of malaria parasites
- Parasite intrinsic factors regulating dormancy or development
- Host factors influencing dormancy and development
- Improved hepatic infection models
