Molecular Developmental Biology

Department

The Molecular Developmental Biology department (part of Radboud Institute for Molecular Life Sciences) focuses on developmental gene regulation, with emphasis on (epi)genomics, transcription and bioinformatics. The research of the department is divided into different groups.

Research groups

Gert Jan Veenstra

Developmental Mechanisms Group
 

Gert Jan Veenstra

The group of Gert Jan Veenstra studies molecular mechanisms underlying stem cell differentiation and heart development, focusing on the dynamic changes in heart cells across the different time spans of embryonic development, adult life (disease), and evolution. The group examines heart development in different species and human stem cell-based models to understand fundamental principles of developmental competence and self-organisation, and the relationship between evolution and development. Deep conservation and differences among species are equally instructive to understand the heart better. With clinical partners, we also study tissue remodelling in human heart disease. By studying chromatin, gene regulation, and single cell trajectories, we aim to uncover fundamental biological principles and discover new avenues for treating disease and advancing regenerative medicine.  

Go to the external website of Veenstra's group

 

Simon van Heeringen

Computational Approaches to Understand Transcription Regulation Group


Simon van Heeringen

The group of Simon van Heeringen combines computational approaches with experimental data to unravel the intricate mechanisms that govern gene regulation and aims to shed light on the underlying processes that drive development, differentiation, and diseases. The research covers the interplay between primary DNA sequence and epigenetic mechanisms and their control of gene expression in two major themes: regulatory sequence analysis, and computational epigenetics.

Klaas Mulder

Epidermal Stem Cell Fate Decisions Group


Klaas Mulder

The group of Klaas Mulder is dedicated to investigating the mechanisms underlying human skin stem cells renewal & differentiation. They focus on studying the epigenetic machinery, which involves chemical modifications of DNA and the role of non-coding RNA molecules. By exploring how different genes and cellular processes work together, they aim to uncover the secrets behind the robustness and precision of biological systems.

 

Rosemary Yu

Comprehensive Model of Cell Behaviour Group


Rosemary Yu

The group of Rosemary Yu focuses on developing tools and mathematical models to understand the connections between gene expression, metabolism, and how cells function in both healthy and diseased states. We take a "vertical" approach, which means we aim to build a comprehensive model of cell behaviour at the molecular level. This model would allow us to simulate different cellular states and predict new strategies for treating diseases that may not have been obvious before. These predictions can then be tested in experiments.

Jo Zhou portrait

Cell Fate Decisions of Epithelial Development and Disease Group


Jo Zhou

The group of Jo Zhou focuses on elucidating the fundamental mechanisms underlying stem cell fate determination, proliferation and differentiation, which are pivotal to human development and diseases pathology. Leveraging systems biology methodologies, including (single-cell) multi-omics and computational integrative analyses, we investigate gene regulation in human stem cells and derived organotypic models, in both healthy and diseased states. Through these studies, we uncover fundamental insights into the regulatory circuitry and mechanisms in stem cells, and offer powerful and effective tools for tissue regeneration and therapeutic intervention.

About Zhou's group

Contact information

Postal address
Postbus 9010
6500GL NIJMEGEN