The Chromatin Structure Group at Radboud Institute for Molecular Life Sciences (RIMLS) research focuses on transcription factors, transcription factor cofactors, histone modifications, SNF2-type ATPase, chromatin looping and SMC-type ATPase bearing protein complexes. We aim to understand how chromosomes are folded inside eukaryotic nuclei and how transcription regulation occurs in this context. This research field has also been called epigenetic regulation.
Chromatin Structure
Research group
Research focus
The group led by Colin Logie studies gene regulation in induced pluripotent stem cells, hematopoietic stem cells and myeloid lineage derived cells. Cells are exposed to glucocorticoids so as to investigate the basis of cell-specific target gene expression by the glucocorticoid receptor at the molecular level, as well as understanding the interplay between glucocorticoid signalling and innate immunity training and tolerance, which are important cell-based aspects of health.
In addition, we develop gene ontology causal activity models (GO-CAM) in collaboration with the Gene Ontology consortium and are happy to involve bachelor and master students in those exercises.
Contact information
Interested in our research or would you like to join our group? Please get in touch with Vesna Andonov.
Location
Visiting address
Geert Grooteplein-Zuid 286525GA Nijmegen
Postal address
Postbus 91016500HB NIJMEGEN