Protein synthesis must be precisely controlled to maintain cellular homeostasis and proteome integrity across tissues and throughout life. Our research explores how the core translation apparatus contributes to these processes, with a particular focus on the biology of tRNAs, ribosome behavior, and quality-control pathways that monitor decoding and protein synthesis. Using a combination of genomics, cell-based models, and mechanistic approaches, we study how disruption of these pathways alters cellular fitness and may create particular vulnerabilities in the nervous system. In this talk, I will discuss recent advances from our work on translational control pathways and their broader implications for neuronal homeostasis and disease.
Danny Nedialkova (she/her)
Professor for Biochemistry
Max Perutz Labs
Dr-Bohr-Gasse 9, 1030 Vienna, AT
Homepage: https://www.maxperutzlabs.ac.at
Tel: +43 1 427761806