As part of the MUSCLE+ study, I conduct research on various arm and leg muscles in adults with the neuromuscular disorder Facioscapulohumeral Dystrophy (FSHD). The goal of my study is to gain a better understanding of the progression of FSHD over time, in order to better support future clinical trials. In clinical practice, various imaging techniques such as ultrasound and MRI are already widely used to assess muscle weakness in FSHD. However, there is not yet one single method that can accurately capture the increase in muscle weakness over time. Measuring the efficiency with which a muscle contracts could be a promising new method for monitoring disease progression.
The MUSCLE+ study is a research project consisting of two different phases. In phase 1, we are conducting a pilot study in a small group of healthy individuals and patients with FSHD. In this phase, we focus primarily on how reliably we can measure the contraction of various arm and leg muscles using ultrasound, muscle strength testing, and muscle function tests. In phase 2, we focus on how efficiently muscles contract during movement in patients with FSHD in comparison to healthy volunteers. After one year, we plan to repeat these measurements to investigate whether any actual changes have occurred over time.
During my Master’s in Biomedical Sciences at Radboud University, I completed an internship within a project focused on developing a neuromuscular care network, under the supervision of Dr. Nicole Voet (rehabilitation physician). It was through this project that I first became acquainted with the neuromuscular disorder FSHD. I knew I wanted to continue working in the field of neuromuscular research, ideally in combination with medical imaging, as I had previously completed a degree in radiologic technology (MBRT). The MUSCLE+ study gave me the opportunity to combine both of these interests.
What I enjoy most about my PhD is the combination of patient interaction and analytical thinking. In this project I carry out a lot of measurements, which allow me to be directly involved with the experiences of patients with FSHD. This helps me to better understand their needs and daily challenges. I can then also apply this knowledge to the scientific aspects of the research.
A big motivation for me in this project is the opportunity to work with highly engaged and enthusiastic patients. Together with the close research group at our department, they are a major source of motivation and energy for me during my PhD.