Advanced Training Organic Synthesis in Early Drug Discovery

This advanced course covers the mechanisms and principles of organic chemistry and aims to elevate them from passive knowledge and perception to a level of thorough understanding and active application.

General

About the training

The main focus of the course Advanced Organic Synthesis is to lift organic chemistry mechanisms and principles from a passive knowledge and perception to a level of thorough understanding and active application. To this end, you will be taught to solve organic chemistry problems by combining an increasing knowledge of organic chemistry principles with chemical logic. The instructor will help you whenever necessary, both in classical classroom form and on an individual basis. This learning involves a thorough repetition of the most important contemporary organic chemistry transformations. A list of name reactions will be provided containing reactions that are supposed to be known and popular reactions that will be discussed in detail. Further specific contents of the course will be highly dynamic, based on recent literature. After this course, participants working at a chemical or pharmaceutical company should be able to propose solutions to synthetic problems they might encounter.

Topics covered:

Oxidations of alcohols to aldehydes and ketones and reduction of aldehydes and ketones to alcohols;
Radical reductions and sigmatropic rearrangements;
Chemistry of imines, iminium ions and nitrilium ions;
Oxidations of alkenes: dihydroxylation, aminohydroxylation and epoxidation;
Palladium-catalyzed cross-coupling reactions;
Substitution reactions;
Chemistry of carbenes and carbenoids and dipolar cycloaddition reactions.

What

What does the training provide?

After successfully completing this course, you are able to:

Solve independently and critically organic synthetic problems that you may come across during your work;
Formulate the mechanisms of important and complex reactions in organic chemistry and predict their regio-, stereo- and enantioselectivity;
Design three/four-step synthesis pathways of small molecules;
Identify and reproduce often applied name reactions;
Discuss and analyze organic chemistry literature and report with the proper chemical nomenclature.

Upon satisfactory attendance and passing the test, participants will receive a Microcredential worth 3 ECTS credits. This digital certificate is stored in the digital backpack and can be shared with colleagues or employers, for example via LinkedIn.

This course was developed with funding from ZonMW

This course was developed with funding from ZonMW (PharmaNL). The aim is to develop an Early Drug Discovery Education Track consisting of eight post-graduate courses that meet the wishes and needs of the business community. We are collaborating with HAN University of Applied Sciences on this project. This project strengthens the current range of pharmaceutical training courses with innovative Early Drug Discovery (EDD) lifelong learning courses. These are intended for employees of companies in the pharmaceutical sector at post-graduate and post-university level. More information can be found on the ZonMW website.

Starting date

To be announced

City

Oss

Costs: on quotation basis

Main Language

English

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Factsheet

Type of education

Training

Result

Edubadge with micro-credential

Organisation

Education for Professionals

Contact information

Do you have a question about this training programme? Or are you curious about how we can develop a fully tailor-made programme for your organisation? If so, please contact us.

Programme

The course is divided into three parts:

Video lectures, as preparation for the actual lectures
Lectures to deepen the information provided in the video lectures
Tutorials

The video lectures are used as preparation for the actual lectures.
Lectures serve to deepen the information provided in the video lectures and to show relevant examples.
The tutorials immediately follow the lectures and are used to make exercises to develop your synthetic expertise and problem-solving synthetic skills. This will involve elucidating reaction mechanism, but also discuss synthesis strategies and retrosynthetic problems. You will work on synthetic schemes where those reactions are used and understand all the synthetic steps of the scheme(s).

Teacher(s)

Teachers

Prof. dr. Floris Rutjes

Professor Synthetic Organic Chemistry

Prof. dr. Floris Rutjes is a specialist in the synthesis of organic molecules. He focuses on:

Developing new and sustainable (catalytic) synthesis methodology;
The design and synthesis of biologically active small molecules;
New click-probes for bio-orthogonal conjugation.

Dr. Pedro Hermkens

Pedro Hermkens (PhD) has a scientific background in organic chemistry, pharmacology and biochemistry. He worked at Organon, Schering-Plough and MSD (Merck) in the Medicinal Chemistry Department for 21 years were he was responsible for projects in several therapeutic areas as team leader. Furthermore, he has experience in the early stage of the process as Discovery Leader. In this role he was responsible for managing target identification & validation, assay development, screening & hit identification & optimization. The last few years he was section head Lead Optimization (Director Medicinal Chemistry) managing 3-4 project teams in parallel from lead to development candidate in different therapeutic areas; immunology, oncology and women’s health. During his career he was heavily involved in combinatorial chemistry, automation of chemistry and library design.

In 2008 he was appointed as extraordinary professor Medicinal Chemistry at Radboud University Nijmegen and in 2013 became director of the Institute Applied BioSciences & Chemistry of the HAN University of Applied Sciences. In 2020 he accepted the position of lector(Applied professor) Drug Discovery at the same university . He is currently retired, but still advisor of Pivot Park.