girl behind computer neurological
girl behind computer neurological

Neurological Disease Modeling - Applications closed

Explore the formation of human neuronal networks and the roots of complex mental disorders. This course combines cutting-edge 'human brain on a chip' techniques with hands-on training in in vitro models, gene-phenotype correlations, and clinical applications like epilepsy.

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    General

    This course has reached the maxim amount of participants and is sold out.

    The Neurological Disease Modeling course equips students with advanced skills in genetics, neurobiology, molecular assays, biophysics, and statistics. This interdisciplinary program empowers participants to design experiments, analyze complex datasets, and interpret findings to uncover the molecular, structural, and functional aspects of neuronal networks. A key focus is placed on the human genetic background and longitudinal studies.

    Participants will gain hands-on experience with advanced techniques to investigate human neuronal networks. They will learn to generate in vitro network models for studying neuronal development in health and disease, as well as acquire practical expertise in obtaining functional data using low- and high-density multi-electrode arrays (MEAs). Additionally, the course introduces epilepsy as a model disorder, showcasing its relevance in bridging clinical needs with experimental approaches. By combining local expertise with guest lectures from clinical and technical experts, the program provides a unique balance of theoretical knowledge and practical skills, preparing participants to excel in neuroscience research.

    Learning objectives

    By the end of the course, participants will:

    1. Be able to design and implement in vitro models for studying human neuronal networks in health and disease
    2. Acquire hands-on expertise in obtaining and analyzing functional data from neuronal networks
    3. Be prepared to apply human neuronal network on a chip methodologies to uncover the molecular, structural, and functional aspects of neuronal networks, with a focus on the human genetic background and longitudinal studies
    4. Understand the clinical context of neurological diseases like epilepsy and how to translate experimental findings into research applications
    5. Develop skills to plan and execute human stem cell-based studies on neuronal networks
    6. Gain insights into the latest experimental and analytical tools used in neuroscience research

    Starting date

    30 June 2025, 8:30 am
    City
    Nijmegen
    Costs
    €888
    Discount
    15% when applying before 1 April 2025
    VAT-free
    Yes
    Educational method
    On-site
    Main Language
    English
    Maximum number of participants
    12

    Factsheet

    Type of education
    Summerschool
    Entry requirements
    Completed BA or MA in (Medical) Biology, Biomedical Sciences, Molecular Life Sciences, Psychology or equivalent. A solid background in cellular and molecular neurobiology is required.
    Study load (ECTS)
    2
    Result
    Certificate, Edubadge

    Contact information

    Radboud Summer School
    Postbus 9102
    6500 HC NIJMEGEN

    radboudsummerschool [at] ru.nl (radboudsummerschool[at]ru[dot]nl)

    Week 2:
     

    Start date: Monday the 30th of June 
     

    End date: Friday the 4th of July

    timetable
    Dirk Schubert

    Dr. Dirk Schubert is associate professor for Translational Neuroscience, senior lecturer and leading his research group for “Cellular Neurophysiology” in the Cognitive Neuroscience Department at the RadboudUMC in Nijmegen. His background is in Biology (PhD in Biology at the Heinrich Heine University of Düsseldorf, Germany) with a particular expertise in electrophysiology and cellular neuroanatomy. His research group focuses on understanding neuronal network formation and maturation in health and neurodevelopmental disorders such as epilepsy, schizophrenia and autism spectrum disorder, with a particular focus on the neuronal circuitries maintaining excitatory/inhibitory balance in rodent ex vivo models as well as human IPSC derived neuronal networks (“human neurological disorders in a dish”). 

    Nael Nadif Kasri

    Prof. dr. N. Nadif Kasri is a professor and scientist at Radboud University, specializing in neuroscience and genetics. His research focuses on uncovering the genetic and molecular mechanisms underlying neurological developmental disorders, with particular attention to conditions such as autism and epilepsy. By exploring these areas, he aims to advance our understanding of these disorders and contribute to the development of new therapeutic approaches. With a strong background in interdisciplinary research, Kasri plays an active role in the field of biomedical sciences, bridging scientific insights to clinical applications.

    Michela Chiappalone smiling

    M. Chiappalone graduated in Electronic Engineering (summa cum laude) in 1999 and obtained a PhD in Electronic Engineering and Computer Science from University of Genova (Italy) in 2003. In 2002 she has been visiting scholar at the Northwestern University in Chicago (USA). After a Post Doc at the University of Genova, in 2007 she joined the Istituto Italiano di Tecnologia (IIT) as a Post Doc. In 2013 she got a Researcher (Team Leader) position in the same Institution. In 2015 she has been Visiting Professor at Kansas University (USA), hosted by Prof. RJ. Nudo. From 2012 to 2015 she has been Coordinator of the FET Open European project BrainBow, judged excellent. In 2018, she joined the Rehab Technologies Lab of IIT. In 2021 she got a professorship position at the University of Genova, where she is now Associate Professor of Bioengineering. She has been named IEEE EMBS Distinguished Lecturer for the years 2021 and 2022. She has been Ad-Com member for IEEE-EMBS and vice-Chair for the IEEE Technical Committee in Neural and Rehabilitation Engineering in 2024. She is now Ex-Com member of IEEE with the position of Vice President Elect for the Technical Activities (VP-TA). She authored 104 publications in International Journals, > 80 peer-reviewed Conference papers and she gave > 100 scientific talks at International/National Conferences and Research Institutions. She is also Editor of 2 Books.

    Juan Burrone smiling

    Juan Burrone is a Professor at the Centre for Developmental Neurobiology and the MRC Centre for Neurodevelopmental Disorders, at King’s College London, UK. He is also the Co-Lead for the Neurodevelopment theme at the Epilepsy Research Institute UK. He graduated from the University of Bristol (UK) in 1995, obtained a PhD from Cambridge University in 2000 and was a postdoctoral fellow at the Molecular and Cellular Biology department at Harvard University, USA, until 2006. He then joined King’s College London as an independent PI. His lab has contributed to our understanding of how connections between neurons form and mature in the brain, how neurons and circuits remain stable over time and how synapses convey information within circuits. Much of this work has focused on uncovering how information is converted from inputs to outputs and makes use of tools that probe neuronal function with good spatio-temporal precision. More recently, he has begun to implement these tools in the study of neuronal function in human neurons, particularly in the fields of epilepsy and neurodegeneration.

    Angelo Accardo smiling

    Angelo Accardo is an Associate Professor at TU Delft in the Precision and Microsystems Engineering department. He co-founded the Delft Young Academy and serves on committees for the Delft Bioengineering Institute and the International Micro and Nanoengineering Conference.

    His research focuses on developing multi-scale 3D fabrication techniques—such as two-photon polymerization and stereolithography—to create engineered microenvironments for studying cell biology and disease models. His work targets applications in brain, cancer, and bone cell research, aiming to reduce animal testing by developing physiologically relevant in-vitro models.

    Dr. Accardo has received multiple NWO grants for projects in brain cancer modeling, stem cell networks, and mechanobiology. He has authored over 60 peer-reviewed papers, contributed to 4 book chapters, and holds a patent on superhydrophobic surfaces. His research has appeared in high-impact journals like Nature Photonics and Advanced Materials. He is also a frequent invited speaker, reviewer, and grant assessor internationally.

    Costs

    Early bird | €754,80

    The deadline for our early bird application is 31 March 2025.

    Regular | €888

    The deadline for our regular application is the 15 May 2025.

    Includes

    Your course, coffee and tea during breaks, warm lunch every day, welcome dinner on Monday, Official Opening, Official Closing.

    Excludes

    Transport, accommodation, social events and other costs. 

    Discounts and scholarships

    There are discounts and scholarships available for our partners. Click below to find out if you are eligible. 

    Discounts and scholarships

    For this course, FENS/IBRO-PERC scholarships are available for students that are located/studying in Europe (but do not reside or study in the Netherlands).

    Find out more

    FENS logo

    Admission

    Level of participant

    Master, PHD, Postdoc.

    Admission requirements

    Completed BA or MA in (Medical) Biology, Biomedical Sciences, Molecular Life Sciences, Psychology or equivalent. A solid background in cellular and molecular neurobiology is required. Having experiences in statistics and in coding (Matlab and Python) are of advantage for the educational outcome. 

    Admission documents

    Motivation letter.