A.A.M. André (Alain)

Employee - Physical Organic Chemistry

A.A.M. André (Alain)
Visiting address

Heyendaalseweg 135
6525 AJ NIJMEGEN
Internal postal code: 50

Postal address

Postbus 9010
6500 GL NIJMEGEN

Working days Monday, Tuesday, Wednesday, Thursday, Friday

Biomolecular condensates, or membraneless organelles are dense liquid droplets, enriched with proteins and nucleic acids. These droplets arise from a process called liquid-liquid phase separation (LLPS), or coacervation. The proteins enriched in these droplets are typically intrinsically disordered and enriched with charged residues, linking them to polyelectrolytes. By mimicking these condensates in a cell-free environment, we aim to better understand the molecular mechanism and principles of LLPS in cells. What are the advantages and disadvantages of condensation?

Alain André received his M.Sc. in molecular life sciences from Radboud University in 2017. During his studies he worked on photo-switchable cell penetrating peptides in the Bio-Organic Chemistry group of Prof. Jan van Hest (Radboud University), biohybrid stomatocyte nanomotors for drug delivery in the group of Systems Chemistry of Prof. Daniela Wilson (Radboud University) and on structural analysis of the motif-B domain of BET-proteins at the Protein Structure Function and Engineering group of Prof Joel Mackay (University of Sydney). In 2018 André started as a PhD candidate at the department of Physical Organic Chemistry of Prof Wilhelm Huck, in the coacervate and soft interfaces group of Dr Evan Spruijt in unravelling the mechanism and function of protein liquid-liquid phase separation by designing what we call artificial organelles.

Research theme Research group

Publications