Prof. R.J.M. Bindels

René Bindels is as physiologist interested in the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular. In addition, the functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia are investigated. The studies include use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity. He is responsible for several physiology courses for medical and health science students. He is an elected member of the Academia Europaea and recipient of the Robert Pitts Lectureship of the International Union of Physiological Sciences, Carl W. Gottschalk Lectureship of the American Physiological Society and Homer Smith award of the American Society of Nephrology. Since 2010 he is the scientific director of the Radboud Institute for Molecular Life Sciences (RIMLS).

• Renal Disorders

• Physiology / Ion Transport