Prof. J.R. Homberg (Judith)

Principal investigator - Donders Center of Medical Neurosciences
Principal investigator - Donders Institute for Brain, Cognition and Behaviour
Professor - Faculty of Medical Sciences

Prof. J.R. Homberg (Judith)
Visiting address

Kapittelweg 29
6525 EN NIJMEGEN
Internal postal code: 205

Postal address

Postbus 9101
6500 HB NIJMEGEN

Our translational animal experimental research focuses on (serotonergic) genetic and environmental factors that influence brain development and behavioural traits. Interactions between these factors may lead to maladaptive emotional responses as seen in stress-related disorders and addiction, but also cognitive improvements, depending on environmental conditions. It is our overarching hypothesis that the cognitive improvements can be used to offset the maladaptive emotional responses. To test this hypothesis we use unique mutant rats that model human genetic polymorphisms, including the serotonin transporter knockout rat. We also investigate the role of serotonin and environmental factors in brain development and long-term effects on behaviour and cognition. Our main expertise is measuring basic and complex (translational) behaviours in rats, which we combine with invasive measurements, pharmacological manipulations, in vivo neurochemical measurements and neuroimaging, molecular genetic analyses, and immunohistochemical assessments.

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About
Judith Homberg examines the factors that affect the development of the brain and behavioural characteristics. The interactions between these two can result in emotional reactions. She believes that the interventions that stimulate this type of development can compensate for these reactions.