Dr J.R. Metz (Juriaan)
Employee - Animal Ecology & Physiology
I am curious to understand how fish deal with changes in their environment. These changes can involve short-term responses (e.g. a stress response), or long-term adaptations in evolutionary contexts. I am particularly interested in the early development of the skeleton and its endocrine regulation. In my research I use a translational approach of applying results from fundamental research to concrete problems in other fields, including biomedical science.
- My research centrals in and around the Radboud Zebrafish Facility. The facility joins a group of active researchers using zebrafish models. We address scientific questions in fundamental and applied research, including (but not limited to) physiology, endocrinology, aquaculture, health and disease. Our mission is to exploit, promote, and increase the value of zebrafish research within the Radboud University and to make societal impact. More information
- Thyroid hormones affect early bone mineralization, and Triac (a thyroid hormone metabolite) exposure in early development affects zebrafish bone and cartilage formation, as well as osteoblast activity. I want to elucidate how thyroid hormones (and specifically Triac) interfere with the uptake of calcium and bone mineralization in developing fish, and whether this trend persists into adulthood.
- I am developing ideas of how climate change may negatively impact development and growth of the skeleton. Since fish are poikilotherms, effects of changes in water temperature will be particularly pronounced. Furthermore, rising carbon dioxide in the atmosphere leads to (ocean) acidification, increasing its acidity which in turn weakens the fish skeleton. This may have severe consequences on fisheries and aquaculture.
- Lost, or intentionally removed dermal skeletal elements regenerate in fish. Our observations that bone-forming cells from regenerating elements escape from negative influence of cortisol is here of great interest. I want to unravel the underlying mechanism of this differential sensitivity and so hope to identify new targets in treatment of glucocorticoid-induced bone loss.
- Adaptation Physiology of Animals
- Additional Internship and Report
- Animal Evolution and Adaptation
- Bachelor Internship and Report
- Biology Essay
- Internship Bachelor Biology
- MSc Human Biology internship
- Master (Medical) Biology SMI/SIS internship
- Master (Medical) Biology education internship
- Master (Medical) Biology research internship 1
- Master (Medical) Biology research internship 2
- Master Thesis (TWM)
- Research Proposal
- Review Article
- Second Internship
- Third Internship
Programme coordinator of the Faculty of Science Honours programme
(01 June 2019)