Dr H.F. Ólafsdóttir (Hauður Freyja)
Assistant professor - Donders Centre for Neuroscience - Neurobiology
Assistant professor - Donders Institute for Brain, Cognition and Behaviour
Heyendaalseweg 135
6525 AJ NIJMEGEN
Internal postal code: 66
Postbus 9010
6500 GL NIJMEGEN
My research group aims to elucidate the neuronal mechanisms that underlie learning and memory, with a particular focus on episodic memory, also known as one-shot memory. To this end, we adopt an ontogenetic approach, studying the developmental timeline of neuronal representations and mechanisms implicated in mature memory and the gradual unfoldment of component memory processes in the early postnatal period. Recently we have also become interested in investigating the role of early life experiences in memory maturation.
To achieve our goals, we study neuronal activity from the developing rodent (rat, mouse) brain using state-of-the-art neuronal recording methods (e.g. in vivo electrophysiology and imaging) and try to relate neurodeveopmental milestones to critical cognitive milestones. For example, we chart the maturation of hippocampal functional representations (e.g. place cells), oscillations and inter-regional communication in tandem with emerging memory capabilities. To study the influence of early life experiences, we use video recordings of rodent litters in their home cages, combined with advanced machine-learning-based behavioral analysis (e.g., pose estimation).
While our work is fundamentally curiosity-driven, it has potential implications for understanding memory-related disorders. Memory dysfunction is a key feature of neurodevelopmental conditions such as autism and schizophrenia, as well as neuropsychiatric (e.g., PTSD) and neurodegenerative disorders (e.g., Alzheimer’s disease). By identifying the essential processes for healthy memory system development, our research may contribute to long-term clinical insights. We are also committed to bridging the gap between animal and human research. We regularly work with researchers studying human development and focus on behaviors that offer strong comparative potential.
My work has been funded by the Donders Mohrmann Fellowship, NWO Aspasia award and Gravitation consortium.