Prof. R.P. van Rij (Ronald)
Professor - Faculty of Medical Sciences (Radboudumc)
Mosquitoes and other blood-feeding insects can transmit important viral pathogens. Some of these arthropod-borne (arbo-)viruses such as dengue and Zika virus are responsible for worldwide epidemics and high mortality rates. Despite the enormous disease burden associated with dengue virus, specific treatment and effective intervention strategies are lacking. Arboviruses replicate efficiently in both mosquito vector and vertebrate host. As a consequence, these viruses interact with host proteins of these diverse hosts and encounter the innate and adaptive immune responses of vertebrates, as well as the — poorly characterized — innate immune system of insects.
The research group of Ronald van Rij studies virus-host interaction in insects and mammals with a major interest in antiviral immunity and small RNA pathways in mosquitoes and the genetic model organisms Drosophila melanogaster (fruit fly). In addition, his group aims to identify and characterize novel inhibitors of dengue and Zika virus. For this work, a biosafety level 3 laboratory and mosquito insectary was established to study pathogenic arboviruses in mosquitoes of the Aedes genus.
Ronald van Rij was awarded several national and international grants, including a Consolidator Grant from the European Research Council (ERC), a Research Grant from the Human Frontiers Science Program (HFSP), and a VICI grant from the Netherlands Organization for Scientific Research (NWO).
In addition to heading the laboratory of experimental virology, Van Rij is responsible for teaching virology and RNA biology in several BSc and MSc programs and is member of the Educational Management team of the Msc program Molecular Mechanisms of Disease (MMD).
- Halbach R, Miesen P, Joosten J, Taşköprü E, Pennings B, Vogels C, Merkling SH, Koenraadt CJ, Lambrechts L, Van Rij RP. 2020. A satellite repeat-derived piRNA controls embryonic development of Aedes. Nature 580:274–277 Full text
- Joosten J, Taşköprü E, Jansen PWTC, Pennings B, Vermeulen M, Van Rij RP. 2021. PIWI proteomics identifies Atari and Pasilla as piRNA biogenesis factors in Aedes mosquitoes. Cell Reports: 35: 109073. Full text
- Bronkhorst AW, Vogels R, Overheul GJ, Pennings B, Gausson-Dorey V, Miesen P, Van Rij RP. 2019. A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila. Proc Natl Acad Sci U S A. 116:24296-24302. Full text
- Merkling SH, Bronkhorst AW, Kramer JM, Overheul GJ, Schenck A, Van Rij RP. 2015. The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila. PLoS Pathogens 11(4):e1004692 Full text
- van Cleef KW, Overheul GJ, Thomassen M, Kaptein SJ, Davidson AD, Jacobs M, Neyts J, van Kuppeveld FJ, and van Rij RP, 2013. Identification of a new Dengue virus inhibitor that restricts genomic RNA replication by targeting the viral NS4B protein. Antiviral Res 99:165-171 Full text
Research grants and prizes
- 2021 - Elected member, Academia Europaea More information
- 2018 - PhD supervisor of the year, Radboud Institute for Molecular Life Sciences (RIMLS)
- 2017 - VICI grant, Netherlands Organization for Scientific Research (NWO)
- 2014 - Consolidator grant, European Research Council (ERC)
- 2010 - Kluyver award, Royal Netherlands Society for Microbiology (KNVM)
- 2022 - Radboudumc Associate Principal Lecturer
- 2020 - Lecturer of the year, MSc program Molecular Mechanisms of Disease.
- 2019 - Radboudumc junior Principal Lecturer
- Additional Internship and Report
- Bachelor Internship and Report
- Immunity related disorders and immunotherapy
- Infectious Diseases
- Internship Bachelor Biology
- MSc Human Biology internship
- Master (Medical) Biology SMI/SIS internship
- Master (Medical) Biology education internship
- Master (Medical) Biology research internship 1
- Master (Medical) Biology research internship 2
- Master Thesis (TWM)
- Medical Microbiology
- RNA Structure and Function
- Research Proposal
- Review Article
- Second Internship
- Third Internship
Editorial board, PLOS Neglected Tropical Diseases
(01 May 2022)
Member, executive board, Netherlands Center for One Health
(01 May 2022)
Netherlands Center for One Health
Member, selection committee for the VIDI grant scheme, Netherlands Organization for Scientific Research (NWO), Sciences domain (2018-2020).
External member, advisory committee Insect viruses, Committee Genetic Modification (COGEM) (2018-2019).
Guest professor, University of Pavia, Italy (2018).
Member, selection committee for the Open program of the division Earth and Life Sciences (ALW), Netherlands Organization for Scientific Research (NWO) (2016).
Board member, study group Nucleic acids, Netherlands Organization for Scientific Research (NWO), Chemical Sciences division (2014-2018).