Prof. M. Vermeulen (Michiel)

Professor - Molecular Biology
Director - Radboud Institute for Molecular Life Sciences, FNWI-deel

Prof. M. Vermeulen (Michiel)
Visiting address

Geert Grooteplein Zuid 28
6525 GA NIJMEGEN
Internal postal code: route 274

Visiting address

Geert Grooteplein Zuid 28
6525 GA NIJMEGEN
Internal postal code: route 274

Postal address

Internal address: M850/3.79 Postbus 9101
6500 HB NIJMEGEN

Working days Monday, Tuesday, Wednesday, Thursday, Friday

The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab is using state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in (differentiated) stem cells. Furthermore, we use the same technology to study deregulation of gene expression in cancer.

Key Publications:

Lindeboom RG, van Voorthuijsen L, ..., Snippert HJ, Vermeulen M. Integrative multi-omics analysis of intestinal organoid differentiation. Mol Syst Biol. 2018 Jun 26;14(6):e8227.

Zhang X, Smits AH, van Tilburg GBA, Jansen PWTC, Makowski MM, Ovaa H, Vermeulen M. An interaction landscape of ubiquitin signaling. Mol Cell 2017 Mar 2;65(5):941-955.e8.

Edupuganti RR, Geiger S, Lindeboom RGH, ..., Stunnenberg HG, He C, Carell T, Vermeulen M. N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis. Nat Struct Mol Biol. 2017 Oct;24(10):870-878.

Kloet SL, Makowski MM, Baymaz HI, ...., Di Croce L, Vermeulen M. The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation. Nat Struct Mol Biol. 2016 Jul;23(7):682-90

Spruijt CG, Gnerlich F, Smits AH, .... Carell T, Vermeulen M. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell. 2013. Feb 28;152(5):1146-59.